Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/21884209http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21884209http://www.w3.org/2000/01/rdf-schema#comment"

Aims

 The up-regulation of the cell adhesion molecule L1 has been associated with impaired prognosis in several cancers. This study aimed to identify potential prognostic markers, including L1, in adenoid cystic carcinoma of the salivary glands (ACCs), which might give additional insight into the molecular mechanisms underlying malignant progression.

Methods and results

The expression of L1 was analysed in 34 primary ACCs (nine tubular, 15 cribriform, nine solid, one mixed) and correlated with recurrence, metastasis, overall survival and clinicopathological parameters. Independent of the histological subtype, intense L1 expression in the primary tumours was associated significantly with metastasis (P = 0.02) and death (P = 0.044). In the subgroup of cribriform ACCs, 10 of 15 tumours contained pseudocysts, which were associated with significantly lower recurrence rates (P = 0.003), lower metastasis rates (P = 0.009) and a prolonged overall survival (P =0.004).

Conclusions

Determination of L1 expression in primary ACCs improves risk estimations. As up-regulation of L1 expression predicts fatal prognosis, L1 might be involved functionally in growth and spread of ACC and might thus present a molecular target for future therapeutic strategies."xsd:string
http://purl.uniprot.org/citations/21884209http://purl.org/dc/terms/identifier"doi:10.1111/j.1365-2559.2011.03895.x"xsd:string
http://purl.uniprot.org/citations/21884209http://purl.uniprot.org/core/author"Altevogt P."xsd:string
http://purl.uniprot.org/citations/21884209http://purl.uniprot.org/core/author"Schumacher U."xsd:string
http://purl.uniprot.org/citations/21884209http://purl.uniprot.org/core/author"Dahl A."xsd:string
http://purl.uniprot.org/citations/21884209http://purl.uniprot.org/core/author"Loning T."xsd:string
http://purl.uniprot.org/citations/21884209http://purl.uniprot.org/core/author"Teegen J."xsd:string
http://purl.uniprot.org/citations/21884209http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/21884209http://purl.uniprot.org/core/name"Histopathology"xsd:string
http://purl.uniprot.org/citations/21884209http://purl.uniprot.org/core/pages"299-307"xsd:string
http://purl.uniprot.org/citations/21884209http://purl.uniprot.org/core/title"Glycoconjugate expression in adenoid cystic carcinoma of the salivary glands: up-regulation of L1 predicts fatal prognosis."xsd:string
http://purl.uniprot.org/citations/21884209http://purl.uniprot.org/core/volume"59"xsd:string
http://purl.uniprot.org/citations/21884209http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/21884209
http://purl.uniprot.org/citations/21884209http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/21884209
http://purl.uniprot.org/uniprot/#_A8K139-mappedCitation-21884209http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21884209
http://purl.uniprot.org/uniprot/#_P32004-mappedCitation-21884209http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21884209
http://purl.uniprot.org/uniprot/#_Q7Z2F9-mappedCitation-21884209http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21884209
http://purl.uniprot.org/uniprot/#_Q7Z2H2-mappedCitation-21884209http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21884209
http://purl.uniprot.org/uniprot/#_Q7Z2I3-mappedCitation-21884209http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21884209
http://purl.uniprot.org/uniprot/#_Q7Z2J0-mappedCitation-21884209http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21884209
http://purl.uniprot.org/uniprot/#_Q7Z2J6-mappedCitation-21884209http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21884209
http://purl.uniprot.org/uniprot/#_Q7Z2J8-mappedCitation-21884209http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21884209
http://purl.uniprot.org/uniprot/#_Q7Z2J9-mappedCitation-21884209http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21884209
http://purl.uniprot.org/uniprot/#_Q86SE4-mappedCitation-21884209http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21884209
▶