| http://purl.uniprot.org/citations/21884525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21884525 | http://www.w3.org/2000/01/rdf-schema#comment | "Fetal alcohol spectrum disorder is estimated to affect 1% of live births. The similarities between children with fetal alcohol syndrome and those with mutations in the gene encoding L1 cell adhesion molecule (L1) implicates L1 as a target of ethanol developmental neurotoxicity. Ethanol specifically inhibits the neurite outgrowth promoting function of L1 at pharmacologic concentrations. Emerging evidence shows that localized disruption of the lipid rafts reduces L1-mediated neurite outgrowth. We hypothesize that ethanol impairment of the association of L1 with lipid rafts is a mechanism underlying ethanol's inhibition of L1-mediated neurite outgrowth. In this study, we examine the effects of ethanol on the association of L1 and lipid rafts. We show that, in vitro, L1 but not N-cadherin shifts into lipid rafts following treatment with 25 mM ethanol. The ethanol concentrations causing this effect are similar to those inhibiting L1-mediated neurite outgrowth. Increasing chain length of the alcohol demonstrates the same cutoff as that previously shown for inhibition of L1-L1 binding. In addition, in cerebellar granule neurons in which lipid rafts are disrupted with methyl-beta-cyclodextrin, the rate of L1-mediated neurite outgrowth on L1-Fc is reduced to background rate and that this background rate is not ethanol sensitive. These data indicate that ethanol may inhibit L1-mediated neurite outgrowth by retarding L1 trafficking through a lipid raft compartment."xsd:string |
| http://purl.uniprot.org/citations/21884525 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1471-4159.2011.07467.x"xsd:string |
| http://purl.uniprot.org/citations/21884525 | http://purl.uniprot.org/core/author | "He M."xsd:string |
| http://purl.uniprot.org/citations/21884525 | http://purl.uniprot.org/core/author | "Tang N."xsd:string |
| http://purl.uniprot.org/citations/21884525 | http://purl.uniprot.org/core/author | "Fox S."xsd:string |
| http://purl.uniprot.org/citations/21884525 | http://purl.uniprot.org/core/author | "Bearer C.F."xsd:string |
| http://purl.uniprot.org/citations/21884525 | http://purl.uniprot.org/core/author | "Farah B."xsd:string |
| http://purl.uniprot.org/citations/21884525 | http://purl.uniprot.org/core/author | "Littner Y."xsd:string |
| http://purl.uniprot.org/citations/21884525 | http://purl.uniprot.org/core/author | "Malouf A."xsd:string |
| http://purl.uniprot.org/citations/21884525 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21884525 | http://purl.uniprot.org/core/name | "J Neurochem"xsd:string |
| http://purl.uniprot.org/citations/21884525 | http://purl.uniprot.org/core/pages | "859-867"xsd:string |
| http://purl.uniprot.org/citations/21884525 | http://purl.uniprot.org/core/title | "Ethanol causes the redistribution of L1 cell adhesion molecule in lipid rafts."xsd:string |
| http://purl.uniprot.org/citations/21884525 | http://purl.uniprot.org/core/volume | "119"xsd:string |
| http://purl.uniprot.org/citations/21884525 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21884525 |
| http://purl.uniprot.org/citations/21884525 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21884525 |
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