| http://purl.uniprot.org/citations/21886181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21886181 | http://www.w3.org/2000/01/rdf-schema#comment | "In C. elegans, the BH3-only domain protein EGL-1, the Apaf-1 homolog CED-4 and the CED-3 caspase are required for apoptosis induction, whereas the Bcl-2 homolog CED-9 prevents apoptosis. Mammalian B-cell lymphoma 2 (Bcl-2) inhibits apoptosis by preventing the release of the Apaf-1 (apoptotic protease-activating factor 1) activator cytochrome c from mitochondria. In contrast, C. elegans CED-9 is thought to inhibit CED-4 by sequestering it at the outer mitochondrial membrane by direct binding. We show that CED-9 associates with the outer mitochondrial membrane within distinct foci that do not overlap with CED-4, which is predominantly perinuclear and does not localize to mitochondria. CED-4 further accumulates in the perinuclear space in response to proapoptotic stimuli such as ionizing radiation. This increased accumulation depends on EGL-1 and is abrogated in ced-9 gain-of-function mutants. CED-4 accumulation is not sufficient to trigger apoptosis execution, even though it may prime cells for apoptosis. Our results suggest that the cell death protection conferred by CED-9 cannot be solely explained by a direct interaction with CED-4."xsd:string |
| http://purl.uniprot.org/citations/21886181 | http://purl.org/dc/terms/identifier | "doi:10.1038/cdd.2011.104"xsd:string |
| http://purl.uniprot.org/citations/21886181 | http://purl.uniprot.org/core/author | "Gartner A."xsd:string |
| http://purl.uniprot.org/citations/21886181 | http://purl.uniprot.org/core/author | "Pourkarimi E."xsd:string |
| http://purl.uniprot.org/citations/21886181 | http://purl.uniprot.org/core/author | "Greiss S."xsd:string |
| http://purl.uniprot.org/citations/21886181 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/21886181 | http://purl.uniprot.org/core/name | "Cell Death Differ"xsd:string |
| http://purl.uniprot.org/citations/21886181 | http://purl.uniprot.org/core/pages | "406-415"xsd:string |
| http://purl.uniprot.org/citations/21886181 | http://purl.uniprot.org/core/title | "Evidence that CED-9/Bcl2 and CED-4/Apaf-1 localization is not consistent with the current model for C. elegans apoptosis induction."xsd:string |
| http://purl.uniprot.org/citations/21886181 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/21886181 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21886181 |
| http://purl.uniprot.org/citations/21886181 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21886181 |
| http://purl.uniprot.org/uniprot/#_P41958-mappedCitation-21886181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21886181 |
| http://purl.uniprot.org/uniprot/#_P30429-mappedCitation-21886181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21886181 |
| http://purl.uniprot.org/uniprot/P30429 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21886181 |
| http://purl.uniprot.org/uniprot/P41958 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21886181 |