| http://purl.uniprot.org/citations/21888897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21888897 | http://www.w3.org/2000/01/rdf-schema#comment | "Despite their structural similarity, hypoxia-inducible factor (HIF)-1α and HIF-2α have distinct functional properties and exhibit distinct spatiotemporal expression patterns, suggesting that the expressions of the two proteins are regulated by different mechanisms. To clarify the HIF-2α-specific regulatory mechanism, we screened HIF-2α-associated proteins in a yeast two-hybrid system and identified kelch-like 20 (KLHL20). HIF-2α, but not HIF-1α, interacted with KLHL20. siRNA-mediated knockdown of KLHL20 decreased HIF-2α protein, but not HIF-2α mRNA or HIF-1α protein. Depletion of KLHL20 decreased hypoxia-induced HIF activity, and consequently resulted in decreased expression levels of HIF-2α-responsive genes such as VEGF and CITED2. In contrast, overexpression of KLHL20 increased the expression levels and transcriptional activities of the O(2)-sensitive wild-type and O(2)-insensitive mutant forms of HIF-2α. KLHL20 siRNA also inhibited HIF-2 activity in von Hippel-Lindau tumor suppressor protein (pVHL)-deficient 786-O cells. These results indicate that KLHL20 is a novel player that regulates HIF-2α protein expression through mechanisms independent of hypoxia and pVHL."xsd:string |
| http://purl.uniprot.org/citations/21888897 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2011.08.058"xsd:string |
| http://purl.uniprot.org/citations/21888897 | http://purl.uniprot.org/core/author | "Ogawa M."xsd:string |
| http://purl.uniprot.org/citations/21888897 | http://purl.uniprot.org/core/author | "Nakano Y."xsd:string |
| http://purl.uniprot.org/citations/21888897 | http://purl.uniprot.org/core/author | "Inui H."xsd:string |
| http://purl.uniprot.org/citations/21888897 | http://purl.uniprot.org/core/author | "Yamaji R."xsd:string |
| http://purl.uniprot.org/citations/21888897 | http://purl.uniprot.org/core/author | "Harada N."xsd:string |
| http://purl.uniprot.org/citations/21888897 | http://purl.uniprot.org/core/author | "Mitani T."xsd:string |
| http://purl.uniprot.org/citations/21888897 | http://purl.uniprot.org/core/author | "Terai T."xsd:string |
| http://purl.uniprot.org/citations/21888897 | http://purl.uniprot.org/core/author | "Higashimura Y."xsd:string |
| http://purl.uniprot.org/citations/21888897 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21888897 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/21888897 | http://purl.uniprot.org/core/pages | "201-205"xsd:string |
| http://purl.uniprot.org/citations/21888897 | http://purl.uniprot.org/core/title | "Kelch-like 20 up-regulates the expression of hypoxia-inducible factor-2alpha through hypoxia- and von Hippel-Lindau tumor suppressor protein-independent regulatory mechanisms."xsd:string |
| http://purl.uniprot.org/citations/21888897 | http://purl.uniprot.org/core/volume | "413"xsd:string |
| http://purl.uniprot.org/citations/21888897 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21888897 |
| http://purl.uniprot.org/citations/21888897 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21888897 |
| http://purl.uniprot.org/uniprot/#_A0A024R2F2-mappedCitation-21888897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21888897 |
| http://purl.uniprot.org/uniprot/#_A4ZYX2-mappedCitation-21888897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21888897 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4K1-mappedCitation-21888897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21888897 |
| http://purl.uniprot.org/uniprot/#_B4E1V7-mappedCitation-21888897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21888897 |
| http://purl.uniprot.org/uniprot/#_A0PJF6-mappedCitation-21888897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21888897 |
| http://purl.uniprot.org/uniprot/#_I6RYK4-mappedCitation-21888897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21888897 |
| http://purl.uniprot.org/uniprot/#_B3KW07-mappedCitation-21888897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21888897 |