| http://purl.uniprot.org/citations/21889502 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21889502 | http://www.w3.org/2000/01/rdf-schema#comment | "Small non-coding RNAs regulate gene expression in a sequence-specific manner. In Drosophila, Dicer-2 (Dcr-2) functions in the biogenesis of endogenous small interfering RNAs (endo-siRNAs). We identified 21 distinct proteins that exhibited a ≥ 1.5-fold change as a consequence of loss of dcr-2 function. Most of these were metabolic genes implicated in stress resistance and aging. dcr-2 Mutants had reduced lifespan and were hypersensitive to oxidative, endoplasmic reticulum, starvation, and cold stresses. Furthermore, loss of dcr-2 function led to abnormal lipid and carbohydrate metabolism. Our results suggest roles for the endo-siRNA pathway in metabolic regulation and defense against stress and aging in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/21889502 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2011.08.034"xsd:string |
| http://purl.uniprot.org/citations/21889502 | http://purl.uniprot.org/core/author | "Kim S."xsd:string |
| http://purl.uniprot.org/citations/21889502 | http://purl.uniprot.org/core/author | "Lee Y.S."xsd:string |
| http://purl.uniprot.org/citations/21889502 | http://purl.uniprot.org/core/author | "Lee L."xsd:string |
| http://purl.uniprot.org/citations/21889502 | http://purl.uniprot.org/core/author | "Hong J.S."xsd:string |
| http://purl.uniprot.org/citations/21889502 | http://purl.uniprot.org/core/author | "Han S.J."xsd:string |
| http://purl.uniprot.org/citations/21889502 | http://purl.uniprot.org/core/author | "Hwang S."xsd:string |
| http://purl.uniprot.org/citations/21889502 | http://purl.uniprot.org/core/author | "Lim D.H."xsd:string |
| http://purl.uniprot.org/citations/21889502 | http://purl.uniprot.org/core/author | "Noh S.H."xsd:string |
| http://purl.uniprot.org/citations/21889502 | http://purl.uniprot.org/core/author | "Oh C.T."xsd:string |
| http://purl.uniprot.org/citations/21889502 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21889502 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/21889502 | http://purl.uniprot.org/core/pages | "3079-3085"xsd:string |
| http://purl.uniprot.org/citations/21889502 | http://purl.uniprot.org/core/title | "The endogenous siRNA pathway in Drosophila impacts stress resistance and lifespan by regulating metabolic homeostasis."xsd:string |
| http://purl.uniprot.org/citations/21889502 | http://purl.uniprot.org/core/volume | "585"xsd:string |
| http://purl.uniprot.org/citations/21889502 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21889502 |
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| http://purl.uniprot.org/uniprot/#_A0A0S0WIH4-mappedCitation-21889502 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21889502 |