| http://purl.uniprot.org/citations/21893041 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21893041 | http://www.w3.org/2000/01/rdf-schema#comment | "Berberine exerts an anti-adipogenic activity that is associated with the down-regulation of C/EBPα and PPARγ. Stimulation of AMP-activated kinase (AMPK) caused by inhibition of mitochondrial respiration has been suggested to underlie such molecular regulation. In the present study, we show that berberine up-regulated the expression of two different sets of C/EBP inhibitors, CHOP and DEC2, while down-modulating C/EBPα, PPARγ and other adipogenic markers and effectors in differentiating 3T3-L1 preadipocytes and mature adipocytes. Data also suggested that the berberine-induced up-regulation of CHOP and DEC2 was attributable to selective activation of an unfolded protein response (UPR) and modified extracellular environment, respectively. As a result, the anti-adipogenic activity of berberine was diminished remarkably by adjusting the differentiation culture media and limitedly but consistently by knockdown of CHOP expression. Together, up-regulation of C/EBP inhibitors appears to underlie the berberine-induced repression of C/EBPα and PPARγ and, so, the inhibition of adipogenesis."xsd:string |
| http://purl.uniprot.org/citations/21893041 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2011.08.110"xsd:string |
| http://purl.uniprot.org/citations/21893041 | http://purl.uniprot.org/core/author | "Shin J."xsd:string |
| http://purl.uniprot.org/citations/21893041 | http://purl.uniprot.org/core/author | "Kwon J."xsd:string |
| http://purl.uniprot.org/citations/21893041 | http://purl.uniprot.org/core/author | "Pham T.P."xsd:string |
| http://purl.uniprot.org/citations/21893041 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21893041 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/21893041 | http://purl.uniprot.org/core/pages | "376-382"xsd:string |
| http://purl.uniprot.org/citations/21893041 | http://purl.uniprot.org/core/title | "Berberine exerts anti-adipogenic activity through up-regulation of C/EBP inhibitors, CHOP and DEC2."xsd:string |
| http://purl.uniprot.org/citations/21893041 | http://purl.uniprot.org/core/volume | "413"xsd:string |
| http://purl.uniprot.org/citations/21893041 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21893041 |
| http://purl.uniprot.org/citations/21893041 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21893041 |
| http://purl.uniprot.org/uniprot/#_D3Z2G6-mappedCitation-21893041 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21893041 |
| http://purl.uniprot.org/uniprot/#_D3YX14-mappedCitation-21893041 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21893041 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VHR8-mappedCitation-21893041 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21893041 |
| http://purl.uniprot.org/uniprot/#_P35639-mappedCitation-21893041 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21893041 |
| http://purl.uniprot.org/uniprot/#_Q3V405-mappedCitation-21893041 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21893041 |
| http://purl.uniprot.org/uniprot/#_Q8CGH4-mappedCitation-21893041 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21893041 |
| http://purl.uniprot.org/uniprot/#_Q99PV5-mappedCitation-21893041 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21893041 |
| http://purl.uniprot.org/uniprot/#_Q6L8F5-mappedCitation-21893041 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21893041 |
| http://purl.uniprot.org/uniprot/A0A2R8VHR8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21893041 |
| http://purl.uniprot.org/uniprot/Q6L8F5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21893041 |
| http://purl.uniprot.org/uniprot/Q99PV5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21893041 |
| http://purl.uniprot.org/uniprot/Q8CGH4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21893041 |