| http://purl.uniprot.org/citations/21898381 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21898381 | http://www.w3.org/2000/01/rdf-schema#comment | "Bone morphogenetic proteins (BMPs) are members of the TGF-β superfamily. TGF-β can affect class switch recombination in human B cells, but whether BMPs also play a role have not been tested. We investigated the functional effects of exogenously added BMPs on CD27(-) naive and CD27(+) memory B cells from healthy donors. BMP-2, -4, -6 and -7 inhibited CD40L/IL-21-induced production of IgM, IgG and IgA. BMP-6 reduced Ig production by 70% in memory B cells and more than 55% in naive B cells, whereas the other BMPs were slightly less potent. We observed a striking difference in functional effects between the structurally similar BMP-6 and BMP-7, as BMP-6 mainly inhibited plasmablast differentiation, and BMP-7 mainly induced apoptosis. In memory B cells, BMP-6 upregulated expression of DNA-binding protein inhibitor genes, but potently inhibited CD40L/IL-21-induced upregulation of the transcription factor XBP1, necessary for the late stages of plasmacytic differentiation. Expression of transcription factors regulating earlier stages (IRF4, PRDM1) was not affected by BMP-6. Taken together, these results show that BMPs are potent suppressors of naive and memory B cells."xsd:string |
| http://purl.uniprot.org/citations/21898381 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201141558"xsd:string |
| http://purl.uniprot.org/citations/21898381 | http://purl.uniprot.org/core/author | "Huse K."xsd:string |
| http://purl.uniprot.org/citations/21898381 | http://purl.uniprot.org/core/author | "Smeland E.B."xsd:string |
| http://purl.uniprot.org/citations/21898381 | http://purl.uniprot.org/core/author | "Stokke T."xsd:string |
| http://purl.uniprot.org/citations/21898381 | http://purl.uniprot.org/core/author | "Oksvold M.P."xsd:string |
| http://purl.uniprot.org/citations/21898381 | http://purl.uniprot.org/core/author | "Forfang L."xsd:string |
| http://purl.uniprot.org/citations/21898381 | http://purl.uniprot.org/core/author | "Myklebust J.H."xsd:string |
| http://purl.uniprot.org/citations/21898381 | http://purl.uniprot.org/core/author | "Bakkebo M."xsd:string |
| http://purl.uniprot.org/citations/21898381 | http://purl.uniprot.org/core/author | "Hilden V.I."xsd:string |
| http://purl.uniprot.org/citations/21898381 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21898381 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/21898381 | http://purl.uniprot.org/core/pages | "3135-3145"xsd:string |
| http://purl.uniprot.org/citations/21898381 | http://purl.uniprot.org/core/title | "Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human B cells: differential effects of BMP-6 and BMP-7."xsd:string |
| http://purl.uniprot.org/citations/21898381 | http://purl.uniprot.org/core/volume | "41"xsd:string |
| http://purl.uniprot.org/citations/21898381 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21898381 |
| http://purl.uniprot.org/citations/21898381 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21898381 |
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| http://purl.uniprot.org/uniprot/#_B4DUF7-mappedCitation-21898381 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21898381 |
| http://purl.uniprot.org/uniprot/#_A8K571-mappedCitation-21898381 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21898381 |
| http://purl.uniprot.org/uniprot/#_B2ZPJ8-mappedCitation-21898381 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21898381 |