| http://purl.uniprot.org/citations/21899704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21899704 | http://www.w3.org/2000/01/rdf-schema#comment | "Dendritic cells recognize pathogens through pattern recognition receptors such as Toll-like receptors and phagocytose and digest them by phagocytic receptors for antigen presentation. This study was designed to clarify the cross-talk between recognition and phagocytosis of microbes in dendritic cells. The murine dendritic cell line XS106 cells were stimulated with the murine C-type lectin SIGNR1 ligand lipoarabinomannan and the Toll-like receptor 2 ligand FSL-1. The co-stimulation significantly suppressed FSL-1-mediated activation of NF-κB as well as production of TNF-α, IL-6 and IL-12p40 in a dose-dependent manner. The suppression was significantly but not completely recovered by knock-down of SIGNR1. SIGNR1 was associated with Toll-like receptor 2 in XS106 cells. The co-stimulation upregulated the expression of suppressor of cytokine signalling-1 in XS106 cells, the knock-down of which almost completely recovered the suppression of the FSL-1-mediated cytokine production by lipoarabinomannan. In addition, it was found that the MyD88-adaptor-like protein in XS106 cells was degraded by co-stimulation with FSL-1 and lipoarabinomannan in the absence, but not the presence, of the proteasome inhibitor MG132 and the degradation was inhibited by knock-down of suppressor of cytokine signalling-1. This study suggests that Toll-like receptor 2-mediated signalling is negatively regulated by SIGNR1-mediated signalling in dendritic cells, possibly through suppressor of cytokine signalling-1-mediated degradation of the MyD88-adaptor-like protein."xsd:string |
| http://purl.uniprot.org/citations/21899704 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1462-5822.2011.01695.x"xsd:string |
| http://purl.uniprot.org/citations/21899704 | http://purl.uniprot.org/core/author | "Shibata K."xsd:string |
| http://purl.uniprot.org/citations/21899704 | http://purl.uniprot.org/core/author | "Totsuka Y."xsd:string |
| http://purl.uniprot.org/citations/21899704 | http://purl.uniprot.org/core/author | "Hasebe A."xsd:string |
| http://purl.uniprot.org/citations/21899704 | http://purl.uniprot.org/core/author | "Ohtani M."xsd:string |
| http://purl.uniprot.org/citations/21899704 | http://purl.uniprot.org/core/author | "Iyori M."xsd:string |
| http://purl.uniprot.org/citations/21899704 | http://purl.uniprot.org/core/author | "Saeki A."xsd:string |
| http://purl.uniprot.org/citations/21899704 | http://purl.uniprot.org/core/author | "Into T."xsd:string |
| http://purl.uniprot.org/citations/21899704 | http://purl.uniprot.org/core/author | "Tanizume N."xsd:string |
| http://purl.uniprot.org/citations/21899704 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/21899704 | http://purl.uniprot.org/core/name | "Cell Microbiol"xsd:string |
| http://purl.uniprot.org/citations/21899704 | http://purl.uniprot.org/core/pages | "40-57"xsd:string |
| http://purl.uniprot.org/citations/21899704 | http://purl.uniprot.org/core/title | "Involvement of suppressor of cytokine signalling-1-mediated degradation of MyD88-adaptor-like protein in the suppression of Toll-like receptor 2-mediated signalling by the murine C-type lectin SIGNR1-mediated signalling."xsd:string |
| http://purl.uniprot.org/citations/21899704 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/21899704 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21899704 |
| http://purl.uniprot.org/citations/21899704 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21899704 |
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| http://purl.uniprot.org/uniprot/#_A0A1S5WLF0-mappedCitation-21899704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21899704 |
| http://purl.uniprot.org/uniprot/#_F6SPW1-mappedCitation-21899704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21899704 |
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| http://purl.uniprot.org/uniprot/#_G3X8Y8-mappedCitation-21899704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21899704 |