| http://purl.uniprot.org/citations/21900177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21900177 | http://www.w3.org/2000/01/rdf-schema#comment | "Costimulation-deficient dendritic cells (DCs) prevent autoimmune disease in mouse models. However, autoimmune-prone mice and humans fail to control expansion of peripheral autoreactive effector memory T cells (T(EMs)), which resist immunoregulation by costimulation-deficient DCs. In contrast, activation of DC costimulation may be coupled with regulatory capacity. To test whether costimulatory DCs control T(EMs) and attenuate established autoimmune disease, we used RelB-deficient mice, which have multiorgan inflammation, expanded peripheral autoreactive T(EMs), and dysfunctional Foxp3(+) regulatory T cells (Tregs) cells and conventional DCs. T(EMs) were regulated by Foxp3(+) Tregs when costimulated by CD3/CD28-coated beads or wild-type DCs but not DCs deficient in RelB or CD80/CD86. After transfer, RelB and CD80/CD86-sufficient DCs restored tolerance and achieved a long-term cure of autoimmune disease through costimulation of T(EM) and Foxp3(+) Treg IFN-γ production, as well as induction of IDO by host APCs. IDO was required for regulation of T(EMs) and suppression of organ inflammation. Our data challenge the paradigm that costimulation-deficient DCs are required to regulate established autoimmune disease to avoid T(EM) activation and demonstrate cooperative cross-talk between costimulatory DCs, IFN-γ, and IDO-dependent immune regulation. IFN-γ and IDO activity may be good surrogate biomarkers measured against clinical efficacy in trials of autoimmune disease immunoregulation."xsd:string |
| http://purl.uniprot.org/citations/21900177 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1101727"xsd:string |
| http://purl.uniprot.org/citations/21900177 | http://purl.uniprot.org/core/author | "Thomas R."xsd:string |
| http://purl.uniprot.org/citations/21900177 | http://purl.uniprot.org/core/author | "An X."xsd:string |
| http://purl.uniprot.org/citations/21900177 | http://purl.uniprot.org/core/author | "Wong M."xsd:string |
| http://purl.uniprot.org/citations/21900177 | http://purl.uniprot.org/core/author | "Pai S."xsd:string |
| http://purl.uniprot.org/citations/21900177 | http://purl.uniprot.org/core/author | "Gerondakis S."xsd:string |
| http://purl.uniprot.org/citations/21900177 | http://purl.uniprot.org/core/author | "Hill G.R."xsd:string |
| http://purl.uniprot.org/citations/21900177 | http://purl.uniprot.org/core/author | "O'Sullivan B.J."xsd:string |
| http://purl.uniprot.org/citations/21900177 | http://purl.uniprot.org/core/author | "MacDonald K.P."xsd:string |
| http://purl.uniprot.org/citations/21900177 | http://purl.uniprot.org/core/author | "Steptoe R.J."xsd:string |
| http://purl.uniprot.org/citations/21900177 | http://purl.uniprot.org/core/author | "Strutton G."xsd:string |
| http://purl.uniprot.org/citations/21900177 | http://purl.uniprot.org/core/author | "Street S."xsd:string |
| http://purl.uniprot.org/citations/21900177 | http://purl.uniprot.org/core/author | "de St Groth B.F."xsd:string |
| http://purl.uniprot.org/citations/21900177 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21900177 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/21900177 | http://purl.uniprot.org/core/pages | "4018-4030"xsd:string |
| http://purl.uniprot.org/citations/21900177 | http://purl.uniprot.org/core/title | "Immunotherapy with costimulatory dendritic cells to control autoimmune inflammation."xsd:string |
| http://purl.uniprot.org/citations/21900177 | http://purl.uniprot.org/core/volume | "187"xsd:string |
| http://purl.uniprot.org/citations/21900177 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21900177 |
| http://purl.uniprot.org/citations/21900177 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21900177 |
| http://purl.uniprot.org/uniprot/#_A0A140LI24-mappedCitation-21900177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21900177 |
| http://purl.uniprot.org/uniprot/#_A0A140LI46-mappedCitation-21900177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21900177 |
| http://purl.uniprot.org/uniprot/#_A0A140LJD6-mappedCitation-21900177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21900177 |