| http://purl.uniprot.org/citations/21903814 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21903814 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21903814 | http://www.w3.org/2000/01/rdf-schema#comment | "Bacterial chromosomes are confined in submicrometer-sized nucleoids. Chromosome organization is facilitated by nucleoid-associated proteins (NAPs), but the mechanisms of action remain elusive. In this work, we used super-resolution fluorescence microscopy, in combination with a chromosome-conformation capture assay, to study the distributions of major NAPs in live Escherichia coli cells. Four NAPs--HU, Fis, IHF, and StpA--were largely scattered throughout the nucleoid. In contrast, H-NS, a global transcriptional silencer, formed two compact clusters per chromosome, driven by oligomerization of DNA-bound H-NS through interactions mediated by the amino-terminal domain of the protein. H-NS sequestered the regulated operons into these clusters and juxtaposed numerous DNA segments broadly distributed throughout the chromosome. Deleting H-NS led to substantial chromosome reorganization. These observations demonstrate that H-NS plays a key role in global chromosome organization in bacteria."xsd:string |
| http://purl.uniprot.org/citations/21903814 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1204697"xsd:string |
| http://purl.uniprot.org/citations/21903814 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1204697"xsd:string |
| http://purl.uniprot.org/citations/21903814 | http://purl.uniprot.org/core/author | "Chen C."xsd:string |
| http://purl.uniprot.org/citations/21903814 | http://purl.uniprot.org/core/author | "Chen C."xsd:string |
| http://purl.uniprot.org/citations/21903814 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/21903814 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/21903814 | http://purl.uniprot.org/core/author | "Xie X.S."xsd:string |
| http://purl.uniprot.org/citations/21903814 | http://purl.uniprot.org/core/author | "Xie X.S."xsd:string |
| http://purl.uniprot.org/citations/21903814 | http://purl.uniprot.org/core/author | "Zhuang X."xsd:string |
| http://purl.uniprot.org/citations/21903814 | http://purl.uniprot.org/core/author | "Zhuang X."xsd:string |
| http://purl.uniprot.org/citations/21903814 | http://purl.uniprot.org/core/author | "Li G.W."xsd:string |
| http://purl.uniprot.org/citations/21903814 | http://purl.uniprot.org/core/author | "Li G.W."xsd:string |
| http://purl.uniprot.org/citations/21903814 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21903814 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21903814 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/21903814 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/21903814 | http://purl.uniprot.org/core/pages | "1445-1449"xsd:string |
| http://purl.uniprot.org/citations/21903814 | http://purl.uniprot.org/core/pages | "1445-1449"xsd:string |
| http://purl.uniprot.org/citations/21903814 | http://purl.uniprot.org/core/title | "Chromosome organization by a nucleoid-associated protein in live bacteria."xsd:string |
| http://purl.uniprot.org/citations/21903814 | http://purl.uniprot.org/core/title | "Chromosome organization by a nucleoid-associated protein in live bacteria."xsd:string |
| http://purl.uniprot.org/citations/21903814 | http://purl.uniprot.org/core/volume | "333"xsd:string |
| http://purl.uniprot.org/citations/21903814 | http://purl.uniprot.org/core/volume | "333"xsd:string |