| http://purl.uniprot.org/citations/21905055 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21905055 | http://www.w3.org/2000/01/rdf-schema#comment | "Hexachloro-1:3-butadiene (HCBD) causes damage specifically to the renal proximal tubule in rats. In the present study, injury to the nephron of male Hanover Wistar rats was characterized at 24 h following dosing with HCBD in the range 5-90 mg kg⁻¹ to determine the most sensitive biomarkers of damage, that is, the biomarkers demonstrating significant changes at the lowest dose of HCBD, using a range of measurements in serum and urine, renal histopathology, and renal and hepatic gene expression. Histologically, kidney degeneration was noted at doses as low as 10 mg kg⁻¹ HCBD. Significant changes in the hepatic and renal gene expression categories of xenobiotic metabolism and oxidative stress were observed at 5 mg kg⁻¹ HCBD, and in the kidney alone, evidence of inflammation at 90 mg kg⁻¹ HCBD. Increases in the urinary excretion of α-glutathione S-transferase (α-GST) and kidney injury molecule-1 (KIM-1) were seen at 10 mg kg⁻¹ HCBD, and increases in urinary excretion of albumin and total protein were evident at 15 mg kg⁻¹ HCBD. The most sensitive, noninvasive biomarkers of HCBD-induced renal toxicity in Hanover Wistar rats were urinary α-GST and KIM-1. Urinary albumin measurement is also recommended as, although it is not the most sensitive biomarker, together with α-GST, albumin showed the largest relative increase of all the biomarkers investigated, and the protein is easily measured."xsd:string |
| http://purl.uniprot.org/citations/21905055 | http://purl.org/dc/terms/identifier | "doi:10.1002/jat.1727"xsd:string |
| http://purl.uniprot.org/citations/21905055 | http://purl.uniprot.org/core/author | "Turton J."xsd:string |
| http://purl.uniprot.org/citations/21905055 | http://purl.uniprot.org/core/author | "Freitas S."xsd:string |
| http://purl.uniprot.org/citations/21905055 | http://purl.uniprot.org/core/author | "Swain A."xsd:string |
| http://purl.uniprot.org/citations/21905055 | http://purl.uniprot.org/core/author | "Bowles J."xsd:string |
| http://purl.uniprot.org/citations/21905055 | http://purl.uniprot.org/core/author | "Francis I."xsd:string |
| http://purl.uniprot.org/citations/21905055 | http://purl.uniprot.org/core/author | "Maguire D."xsd:string |
| http://purl.uniprot.org/citations/21905055 | http://purl.uniprot.org/core/author | "York M."xsd:string |
| http://purl.uniprot.org/citations/21905055 | http://purl.uniprot.org/core/author | "Gandhi M."xsd:string |
| http://purl.uniprot.org/citations/21905055 | http://purl.uniprot.org/core/author | "Pereira I."xsd:string |
| http://purl.uniprot.org/citations/21905055 | http://purl.uniprot.org/core/author | "Smyth R."xsd:string |
| http://purl.uniprot.org/citations/21905055 | http://purl.uniprot.org/core/author | "Scudamore C."xsd:string |
| http://purl.uniprot.org/citations/21905055 | http://purl.uniprot.org/core/author | "Ashall H."xsd:string |
| http://purl.uniprot.org/citations/21905055 | http://purl.uniprot.org/core/author | "Munday M."xsd:string |
| http://purl.uniprot.org/citations/21905055 | http://purl.uniprot.org/core/author | "Sondh S."xsd:string |
| http://purl.uniprot.org/citations/21905055 | http://purl.uniprot.org/core/author | "Stamp C."xsd:string |
| http://purl.uniprot.org/citations/21905055 | http://purl.uniprot.org/core/author | "Woodfine J."xsd:string |
| http://purl.uniprot.org/citations/21905055 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/21905055 | http://purl.uniprot.org/core/name | "J Appl Toxicol"xsd:string |
| http://purl.uniprot.org/citations/21905055 | http://purl.uniprot.org/core/pages | "417-428"xsd:string |
| http://purl.uniprot.org/citations/21905055 | http://purl.uniprot.org/core/title | "Nephrotoxicity of hexachloro-1:3-butadiene in the male Hanover Wistar rat; correlation of minimal histopathological changes with biomarkers of renal injury."xsd:string |
| http://purl.uniprot.org/citations/21905055 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/21905055 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21905055 |