| http://purl.uniprot.org/citations/21908731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21908731 | http://www.w3.org/2000/01/rdf-schema#comment | "Immunopathology is a major cause of influenza-associated morbidity and mortality worldwide. However, the role and regulatory mechanisms of CD4 T cells in severe lung immunopathology following acute influenza infection are poorly understood. In this paper, we report that the emergence of immunopathogenic CD4 T cells is under the control of a transmembrane immunoadaptor DAP12 pathway during influenza infection. We find that the mice lacking DAP12 have unaltered viral clearance but easily succumb to influenza infection as a result of uncontrolled immunopathology. Such immunopathology is associated with markedly increased CD4 T cells displaying markedly increased cytotoxicity and Fas ligand expression. Furthermore, the immunopathogenic property of these CD4 T cells is transferrable. Thus, depletion of CD4 T cells or abrogation of Fas/Fas ligand signaling pathway improves survival and immunopathology. We further find that DAP12 expressed by dendritic cells plays an important role in controlling the immunopathogenic CD4 T cells during influenza infection. Our findings identify a novel pathway that controls the level of immune-pathogenic CD4 T cells during acute influenza infection."xsd:string |
| http://purl.uniprot.org/citations/21908731 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1101050"xsd:string |
| http://purl.uniprot.org/citations/21908731 | http://purl.uniprot.org/core/author | "Aoki N."xsd:string |
| http://purl.uniprot.org/citations/21908731 | http://purl.uniprot.org/core/author | "Horvath C."xsd:string |
| http://purl.uniprot.org/citations/21908731 | http://purl.uniprot.org/core/author | "McCormick S."xsd:string |
| http://purl.uniprot.org/citations/21908731 | http://purl.uniprot.org/core/author | "Takai T."xsd:string |
| http://purl.uniprot.org/citations/21908731 | http://purl.uniprot.org/core/author | "Brown E.G."xsd:string |
| http://purl.uniprot.org/citations/21908731 | http://purl.uniprot.org/core/author | "Small C.L."xsd:string |
| http://purl.uniprot.org/citations/21908731 | http://purl.uniprot.org/core/author | "Xing Z."xsd:string |
| http://purl.uniprot.org/citations/21908731 | http://purl.uniprot.org/core/author | "Damjanovic D."xsd:string |
| http://purl.uniprot.org/citations/21908731 | http://purl.uniprot.org/core/author | "Shaler C.R."xsd:string |
| http://purl.uniprot.org/citations/21908731 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21908731 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/21908731 | http://purl.uniprot.org/core/pages | "4280-4292"xsd:string |
| http://purl.uniprot.org/citations/21908731 | http://purl.uniprot.org/core/title | "Control of pathogenic CD4 T cells and lethal immunopathology by signaling immunoadaptor DAP12 during influenza infection."xsd:string |
| http://purl.uniprot.org/citations/21908731 | http://purl.uniprot.org/core/volume | "187"xsd:string |
| http://purl.uniprot.org/citations/21908731 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21908731 |
| http://purl.uniprot.org/citations/21908731 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21908731 |
| http://purl.uniprot.org/uniprot/#_A0A140LHP7-mappedCitation-21908731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21908731 |
| http://purl.uniprot.org/uniprot/#_A0A140LI31-mappedCitation-21908731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21908731 |
| http://purl.uniprot.org/uniprot/#_O54885-mappedCitation-21908731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21908731 |
| http://purl.uniprot.org/uniprot/#_Q3U419-mappedCitation-21908731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21908731 |
| http://purl.uniprot.org/uniprot/A0A140LI31 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21908731 |
| http://purl.uniprot.org/uniprot/A0A140LHP7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21908731 |