| http://purl.uniprot.org/citations/21909072 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21909072 | http://www.w3.org/2000/01/rdf-schema#comment | "While the pro-differentiation and tumour suppressive functions of Notch signalling in keratinocytes are well established, the underlying mechanisms remain poorly understood. We report here that interferon regulatory factor 6 (IRF6), an IRF family member with an essential role in epidermal development, is induced in differentiation through a Notch-dependent mechanism and is a primary Notch target in keratinocytes and keratinocyte-derived SCC cells. Increased IRF6 expression contributes to the impact of Notch activation on growth/differentiation-related genes, while it is not required for induction of 'canonical' Notch targets like p21(WAF1/Cip1), Hes1 and Hey1. Down-modulation of IRF6 counteracts differentiation of primary human keratinocytes in vitro and in vivo, promoting ras-induced tumour formation. The clinical relevance of these findings is illustrated by the strikingly opposite pattern of expression of Notch1 and IRF6 versus epidermal growth factor receptor in a cohort of clinical SCCs, as a function of their grade of differentiation. Thus, IRF6 is a primary Notch target in keratinocytes, which contributes to the role of this pathway in differentiation and tumour suppression."xsd:string |
| http://purl.uniprot.org/citations/21909072 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2011.325"xsd:string |
| http://purl.uniprot.org/citations/21909072 | http://purl.uniprot.org/core/author | "Dixon M.J."xsd:string |
| http://purl.uniprot.org/citations/21909072 | http://purl.uniprot.org/core/author | "Dotto G.P."xsd:string |
| http://purl.uniprot.org/citations/21909072 | http://purl.uniprot.org/core/author | "Ryan R.J."xsd:string |
| http://purl.uniprot.org/citations/21909072 | http://purl.uniprot.org/core/author | "Radtke F."xsd:string |
| http://purl.uniprot.org/citations/21909072 | http://purl.uniprot.org/core/author | "Di Piazza M."xsd:string |
| http://purl.uniprot.org/citations/21909072 | http://purl.uniprot.org/core/author | "Nguyen B.C."xsd:string |
| http://purl.uniprot.org/citations/21909072 | http://purl.uniprot.org/core/author | "Dziunycz P."xsd:string |
| http://purl.uniprot.org/citations/21909072 | http://purl.uniprot.org/core/author | "Lefort K."xsd:string |
| http://purl.uniprot.org/citations/21909072 | http://purl.uniprot.org/core/author | "Hofbauer G.F."xsd:string |
| http://purl.uniprot.org/citations/21909072 | http://purl.uniprot.org/core/author | "Restivo G."xsd:string |
| http://purl.uniprot.org/citations/21909072 | http://purl.uniprot.org/core/author | "Ozuysal O.Y."xsd:string |
| http://purl.uniprot.org/citations/21909072 | http://purl.uniprot.org/core/author | "Ristorcelli E."xsd:string |
| http://purl.uniprot.org/citations/21909072 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21909072 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/21909072 | http://purl.uniprot.org/core/pages | "4571-4585"xsd:string |
| http://purl.uniprot.org/citations/21909072 | http://purl.uniprot.org/core/title | "IRF6 is a mediator of Notch pro-differentiation and tumour suppressive function in keratinocytes."xsd:string |
| http://purl.uniprot.org/citations/21909072 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/21909072 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21909072 |
| http://purl.uniprot.org/citations/21909072 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21909072 |
| http://purl.uniprot.org/uniprot/#_D3Z7K2-mappedCitation-21909072 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21909072 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1K8-mappedCitation-21909072 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21909072 |
| http://purl.uniprot.org/uniprot/#_B2R762-mappedCitation-21909072 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21909072 |