| http://purl.uniprot.org/citations/21909098 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21909098 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21909098 | http://www.w3.org/2000/01/rdf-schema#comment | "Angiogenesis, the growth of new blood vessels, involves specification of endothelial cells to tip cells and stalk cells, which is controlled by Notch signalling, whereas vascular endothelial growth factor receptor (VEGFR)-2 and VEGFR-3 have been implicated in angiogenic sprouting. Surprisingly, we found that endothelial deletion of Vegfr3, but not VEGFR-3-blocking antibodies, postnatally led to excessive angiogenic sprouting and branching, and decreased the level of Notch signalling, indicating that VEGFR-3 possesses passive and active signalling modalities. Furthermore, macrophages expressing the VEGFR-3 and VEGFR-2 ligand VEGF-C localized to vessel branch points, and Vegfc heterozygous mice exhibited inefficient angiogenesis characterized by decreased vascular branching. FoxC2 is a known regulator of Notch ligand and target gene expression, and Foxc2(+/-);Vegfr3(+/-) compound heterozygosity recapitulated homozygous loss of Vegfr3. These results indicate that macrophage-derived VEGF-C activates VEGFR-3 in tip cells to reinforce Notch signalling, which contributes to the phenotypic conversion of endothelial cells at fusion points of vessel sprouts."xsd:string |
| http://purl.uniprot.org/citations/21909098 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb2331"xsd:string |
| http://purl.uniprot.org/citations/21909098 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb2331"xsd:string |
| http://purl.uniprot.org/citations/21909098 | http://purl.uniprot.org/core/author | "Zheng W."xsd:string |
| http://purl.uniprot.org/citations/21909098 | http://purl.uniprot.org/core/author | "Zheng W."xsd:string |
| http://purl.uniprot.org/citations/21909098 | http://purl.uniprot.org/core/author | "Miura N."xsd:string |
| http://purl.uniprot.org/citations/21909098 | http://purl.uniprot.org/core/author | "Miura N."xsd:string |
| http://purl.uniprot.org/citations/21909098 | http://purl.uniprot.org/core/author | "Aranda E."xsd:string |
| http://purl.uniprot.org/citations/21909098 | http://purl.uniprot.org/core/author | "Aranda E."xsd:string |
| http://purl.uniprot.org/citations/21909098 | http://purl.uniprot.org/core/author | "Fruttiger M."xsd:string |
| http://purl.uniprot.org/citations/21909098 | http://purl.uniprot.org/core/author | "Fruttiger M."xsd:string |
| http://purl.uniprot.org/citations/21909098 | http://purl.uniprot.org/core/author | "Alitalo K."xsd:string |
| http://purl.uniprot.org/citations/21909098 | http://purl.uniprot.org/core/author | "Alitalo K."xsd:string |
| http://purl.uniprot.org/citations/21909098 | http://purl.uniprot.org/core/author | "Tammela T."xsd:string |
| http://purl.uniprot.org/citations/21909098 | http://purl.uniprot.org/core/author | "Tammela T."xsd:string |
| http://purl.uniprot.org/citations/21909098 | http://purl.uniprot.org/core/author | "Gerhardt H."xsd:string |
| http://purl.uniprot.org/citations/21909098 | http://purl.uniprot.org/core/author | "Gerhardt H."xsd:string |
| http://purl.uniprot.org/citations/21909098 | http://purl.uniprot.org/core/author | "Jakobsson L."xsd:string |
| http://purl.uniprot.org/citations/21909098 | http://purl.uniprot.org/core/author | "Jakobsson L."xsd:string |
| http://purl.uniprot.org/citations/21909098 | http://purl.uniprot.org/core/author | "Pollard J.W."xsd:string |
| http://purl.uniprot.org/citations/21909098 | http://purl.uniprot.org/core/author | "Pollard J.W."xsd:string |
| http://purl.uniprot.org/citations/21909098 | http://purl.uniprot.org/core/author | "Eichmann A."xsd:string |
| http://purl.uniprot.org/citations/21909098 | http://purl.uniprot.org/core/author | "Eichmann A."xsd:string |