| http://purl.uniprot.org/citations/21910972 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21910972 | http://www.w3.org/2000/01/rdf-schema#comment | "The cellular RIG-I-like receptor (RLR) senses pathogenic RNA molecular patterns and transmits signals for type I interferon (IFN) production. It acts as a center for antiviral responses, and large numbers of RIG-I (retinoic acid inducible gene-I) interacting proteins are identified as signaling regulators. In the present study, we report PRKRIR, a negative regulator of PKR inhibitor, as a novel RIG-I interacting protein. In HEK293FT cells, PRKRIR synergistically enhances type I IFN production mediated by a signal activated- or constitutively active form of RIG-I. The C-terminal domain of the PRKRIR was required for physical interaction and the signal augmentation. The PRKRIR blocks poly-ubiquitination and protein degradation of RIG-I, thereby increasing cellular levels of RIG-I proteins. Furthermore, overexpression of PRKRIR, along with a signal activated- or constitutively active form of RIG-I, efficiently inhibits virus replication in the infected host. In conclusion, PRKRIR provides a novel positive regulator controlling the RIG-I-IFN production system through protein stability control."xsd:string |
| http://purl.uniprot.org/citations/21910972 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2011.08.127"xsd:string |
| http://purl.uniprot.org/citations/21910972 | http://purl.uniprot.org/core/author | "Yoo J.Y."xsd:string |
| http://purl.uniprot.org/citations/21910972 | http://purl.uniprot.org/core/author | "Now H."xsd:string |
| http://purl.uniprot.org/citations/21910972 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21910972 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/21910972 | http://purl.uniprot.org/core/pages | "487-493"xsd:string |
| http://purl.uniprot.org/citations/21910972 | http://purl.uniprot.org/core/title | "A protein-kinase, IFN-inducible double-stranded RNA dependent inhibitor and repressor of p58 (PRKRIR) enhances type I IFN-mediated antiviral response through the stability control of RIG-I protein."xsd:string |
| http://purl.uniprot.org/citations/21910972 | http://purl.uniprot.org/core/volume | "413"xsd:string |
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