| http://purl.uniprot.org/citations/21911464 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21911464 | http://www.w3.org/2000/01/rdf-schema#comment | "We have previously revealed the protective role of CD8(+) T cells in host defense against Histoplasma capsulatum in animals with CD4(+) T cell deficiency and demonstrated that sensitized CD8(+) T cells are restimulated in vitro by dendritic cells that have ingested apoptotic macrophage-associated Histoplasma antigen. Here we show that immunization with apoptotic phagocytes containing heat-killed Histoplasma efficiently activated functional CD8(+) T cells whose contribution was equal to that of CD4(+) T cells in protection against Histoplasma challenge. Inhibition of macrophage apoptosis due to inducible nitric oxide synthase (iNOS) deficiency or by caspase inhibitor treatment dampened the CD8(+) T cell but not the CD4(+) T cell response to pulmonary Histoplasma infection. In mice subcutaneously immunized with viable Histoplasma yeasts whose CD8(+) T cells are protective against Histoplasma challenge, there was heavy granulocyte and macrophage infiltration and the infiltrating cells became apoptotic. In mice subcutaneously immunized with carboxyfluorescein diacetate succinimidyl ester (CFSE)-labeled apoptotic macrophages containing heat-killed Histoplasma, the CFSE-labeled macrophage material was found to localize within dendritic cells in the draining lymph node. Moreover, depleting dendritic cells in immunized CD11c-DTR mice significantly reduced CD8(+) T cell activation. Taken together, our results revealed that phagocyte apoptosis in the Histoplasma-infected host is associated with CD8(+) T cell activation and that immunization with apoptotic phagocytes containing heat-killed Histoplasma efficiently evokes a protective CD8(+) T cell response. These results suggest that employing apoptotic phagocytes as antigen donor cells is a viable approach for the development of efficacious vaccines to elicit strong CD8(+) T cell as well as CD4(+) T cell responses to Histoplasma infection."xsd:string |
| http://purl.uniprot.org/citations/21911464 | http://purl.org/dc/terms/identifier | "doi:10.1128/iai.05350-11"xsd:string |
| http://purl.uniprot.org/citations/21911464 | http://purl.uniprot.org/core/author | "Wu S.Y."xsd:string |
| http://purl.uniprot.org/citations/21911464 | http://purl.uniprot.org/core/author | "Huang J.H."xsd:string |
| http://purl.uniprot.org/citations/21911464 | http://purl.uniprot.org/core/author | "Lin J.S."xsd:string |
| http://purl.uniprot.org/citations/21911464 | http://purl.uniprot.org/core/author | "Chu C.L."xsd:string |
| http://purl.uniprot.org/citations/21911464 | http://purl.uniprot.org/core/author | "Kung J.T."xsd:string |
| http://purl.uniprot.org/citations/21911464 | http://purl.uniprot.org/core/author | "Wu-Hsieh B.A."xsd:string |
| http://purl.uniprot.org/citations/21911464 | http://purl.uniprot.org/core/author | "Hsieh S.H."xsd:string |
| http://purl.uniprot.org/citations/21911464 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21911464 | http://purl.uniprot.org/core/name | "Infect Immun"xsd:string |
| http://purl.uniprot.org/citations/21911464 | http://purl.uniprot.org/core/pages | "4493-4502"xsd:string |
| http://purl.uniprot.org/citations/21911464 | http://purl.uniprot.org/core/title | "Immunization with apoptotic phagocytes containing Histoplasma capsulatum activates functional CD8(+) T cells to protect against histoplasmosis."xsd:string |
| http://purl.uniprot.org/citations/21911464 | http://purl.uniprot.org/core/volume | "79"xsd:string |
| http://purl.uniprot.org/citations/21911464 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21911464 |
| http://purl.uniprot.org/citations/21911464 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21911464 |
| http://purl.uniprot.org/uniprot/#_A0A1L1STZ4-mappedCitation-21911464 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21911464 |
| http://purl.uniprot.org/uniprot/#_D3YC69-mappedCitation-21911464 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21911464 |
| http://purl.uniprot.org/uniprot/#_P29477-mappedCitation-21911464 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21911464 |
| http://purl.uniprot.org/uniprot/#_P01887-mappedCitation-21911464 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21911464 |
| http://purl.uniprot.org/uniprot/#_Q3U679-mappedCitation-21911464 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21911464 |
| http://purl.uniprot.org/uniprot/#_Q9D239-mappedCitation-21911464 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21911464 |
| http://purl.uniprot.org/uniprot/P01887 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21911464 |
| http://purl.uniprot.org/uniprot/A0A1L1STZ4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21911464 |