| http://purl.uniprot.org/citations/21913799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21913799 | http://www.w3.org/2000/01/rdf-schema#comment | "Transforming growth factor-β (TGF-β) can mediate proteoglycan synthesis via Smad and non-Smad signalling pathways in vascular smooth muscle (VSM). We investigated whether TGF-β-mediated proteoglycan synthesis is via PI3K/Akt. TGF-β induced a rapid phosphorylation of Akt that continued upto 4 h. Akt phosphorylation was blocked by Akt1/2 inhibitor SN30978; however, it did not block Smad2 phosphorylation at either the carboxy or linker regions indicating that TGF-β-mediated Akt phosphorylation is independent of Smad2 signalling. The role of Akt in TGF-β-mediated proteoglycan synthesis was investigated. Treatment with SN30978 showed a concentration-dependent decrease in TGF-β-mediated [(35)S]-sulphate and [(35)S]-Met/Cys incorporation into secreted proteoglycans; however, SDS-PAGE showed no change in biglycan size. In TGF-β-treated cells, biglycan mRNA levels increased by 40-100% in 24 h and was significantly blocked by SN30978. Our findings demonstrate that Akt is a downstream signalling component of TGF-β-mediated biglycan core protein synthesis but not glycosaminoglycan chain hyper-elongation in VSM."xsd:string |
| http://purl.uniprot.org/citations/21913799 | http://purl.org/dc/terms/identifier | "doi:10.3109/08977194.2011.615747"xsd:string |
| http://purl.uniprot.org/citations/21913799 | http://purl.uniprot.org/core/author | "Zheng W."xsd:string |
| http://purl.uniprot.org/citations/21913799 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/21913799 | http://purl.uniprot.org/core/author | "Wang R."xsd:string |
| http://purl.uniprot.org/citations/21913799 | http://purl.uniprot.org/core/author | "Little P.J."xsd:string |
| http://purl.uniprot.org/citations/21913799 | http://purl.uniprot.org/core/author | "Burch M."xsd:string |
| http://purl.uniprot.org/citations/21913799 | http://purl.uniprot.org/core/author | "Osman N."xsd:string |
| http://purl.uniprot.org/citations/21913799 | http://purl.uniprot.org/core/author | "Getachew R."xsd:string |
| http://purl.uniprot.org/citations/21913799 | http://purl.uniprot.org/core/author | "Lancaster G."xsd:string |
| http://purl.uniprot.org/citations/21913799 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21913799 | http://purl.uniprot.org/core/name | "Growth Factors"xsd:string |
| http://purl.uniprot.org/citations/21913799 | http://purl.uniprot.org/core/pages | "203-210"xsd:string |
| http://purl.uniprot.org/citations/21913799 | http://purl.uniprot.org/core/title | "TGF-beta stimulates biglycan core protein synthesis but not glycosaminoglycan chain elongation via Akt phosphorylation in vascular smooth muscle."xsd:string |
| http://purl.uniprot.org/citations/21913799 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/21913799 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21913799 |
| http://purl.uniprot.org/citations/21913799 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21913799 |
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| http://purl.uniprot.org/uniprot/#_A0A078BFK3-mappedCitation-21913799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21913799 |
| http://purl.uniprot.org/uniprot/#_A0A510GAF6-mappedCitation-21913799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21913799 |
| http://purl.uniprot.org/uniprot/#_B3KVH4-mappedCitation-21913799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21913799 |