| http://purl.uniprot.org/citations/21918225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21918225 | http://www.w3.org/2000/01/rdf-schema#comment | "UV irradiation is one of the major external insults to cells and can cause skin aging and cancer. In response to UV light-induced DNA damage, the nucleotide excision repair (NER) pathways are activated to remove DNA lesions. We report here that testicular nuclear receptor 4 (TR4), a member of the nuclear receptor family, modulates DNA repair specifically through the transcription-coupled (TC) NER pathway but not the global genomic NER pathway. The level of Cockayne syndrome B protein (CSB), a member of the TC-NER pathway, is 10-fold reduced in TR4-deficient mouse tissues, and TR4 directly regulates CSB at the transcriptional level. Moreover, restored CSB expression rescues UV hypersensitivity of TR4-deficient cells. Together, these results indicate that TR4 modulates UV sensitivity by promoting the TC-NER DNA repair pathway through transcriptional regulation of CSB. These results may lead to the development of new treatments for UV light-sensitive syndromes, skin cancer, and aging."xsd:string |
| http://purl.uniprot.org/citations/21918225 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m111.259523"xsd:string |
| http://purl.uniprot.org/citations/21918225 | http://purl.uniprot.org/core/author | "Chang C."xsd:string |
| http://purl.uniprot.org/citations/21918225 | http://purl.uniprot.org/core/author | "Li G."xsd:string |
| http://purl.uniprot.org/citations/21918225 | http://purl.uniprot.org/core/author | "Liu S."xsd:string |
| http://purl.uniprot.org/citations/21918225 | http://purl.uniprot.org/core/author | "Wu Q."xsd:string |
| http://purl.uniprot.org/citations/21918225 | http://purl.uniprot.org/core/author | "Chen L.M."xsd:string |
| http://purl.uniprot.org/citations/21918225 | http://purl.uniprot.org/core/author | "Ting H.J."xsd:string |
| http://purl.uniprot.org/citations/21918225 | http://purl.uniprot.org/core/author | "Lee Y.F."xsd:string |
| http://purl.uniprot.org/citations/21918225 | http://purl.uniprot.org/core/author | "Liu N.C."xsd:string |
| http://purl.uniprot.org/citations/21918225 | http://purl.uniprot.org/core/author | "Yan S.J."xsd:string |
| http://purl.uniprot.org/citations/21918225 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21918225 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/21918225 | http://purl.uniprot.org/core/pages | "38103-38108"xsd:string |
| http://purl.uniprot.org/citations/21918225 | http://purl.uniprot.org/core/title | "Testicular nuclear receptor 4 (TR4) regulates UV light-induced responses via Cockayne syndrome B protein-mediated transcription-coupled DNA repair."xsd:string |
| http://purl.uniprot.org/citations/21918225 | http://purl.uniprot.org/core/volume | "286"xsd:string |
| http://purl.uniprot.org/citations/21918225 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21918225 |
| http://purl.uniprot.org/citations/21918225 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21918225 |
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| http://purl.uniprot.org/uniprot/#_A8K4Q3-mappedCitation-21918225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21918225 |
| http://purl.uniprot.org/uniprot/#_A0JP10-mappedCitation-21918225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21918225 |
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| http://purl.uniprot.org/uniprot/#_P49116-mappedCitation-21918225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21918225 |