| http://purl.uniprot.org/citations/21925384 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21925384 | http://www.w3.org/2000/01/rdf-schema#comment | "The translation, localization, and degradation of cytoplasmic mRNAs are controlled by the formation and rearrangement of their mRNPs. The conserved Ded1/DDX3 DEAD-box protein functions in an unknown manner to affect both translation initiation and repression. We demonstrate that Ded1 first functions by directly interacting with eIF4G to assemble a Ded1-mRNA-eIF4F complex, which accumulates in stress granules. After ATP hydrolysis by Ded1, the mRNP exits stress granules and completes translation initiation. Thus, Ded1 functions both as a repressor of translation, by assembling an mRNP stalled in translation initiation, and as an ATP-dependent activator of translation, by resolving the stalled mRNP. These results identify Ded1 as a translation initiation factor that assembles and remodels an intermediate complex in translation initiation."xsd:string |
| http://purl.uniprot.org/citations/21925384 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2011.08.008"xsd:string |
| http://purl.uniprot.org/citations/21925384 | http://purl.uniprot.org/core/author | "Gao Z."xsd:string |
| http://purl.uniprot.org/citations/21925384 | http://purl.uniprot.org/core/author | "Parker R."xsd:string |
| http://purl.uniprot.org/citations/21925384 | http://purl.uniprot.org/core/author | "Jankowsky E."xsd:string |
| http://purl.uniprot.org/citations/21925384 | http://purl.uniprot.org/core/author | "Hilliker A."xsd:string |
| http://purl.uniprot.org/citations/21925384 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21925384 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/21925384 | http://purl.uniprot.org/core/pages | "962-972"xsd:string |
| http://purl.uniprot.org/citations/21925384 | http://purl.uniprot.org/core/title | "The DEAD-box protein Ded1 modulates translation by the formation and resolution of an eIF4F-mRNA complex."xsd:string |
| http://purl.uniprot.org/citations/21925384 | http://purl.uniprot.org/core/volume | "43"xsd:string |
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