| http://purl.uniprot.org/citations/21926968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21926968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21926968 | http://www.w3.org/2000/01/rdf-schema#comment | "Synaptic transmission relies on effective and accurate compensatory endocytosis. F-BAR proteins may serve as membrane curvature sensors and/or inducers and thereby support membrane remodelling processes; yet, their in vivo functions urgently await disclosure. We demonstrate that the F-BAR protein syndapin I is crucial for proper brain function. Syndapin I knockout (KO) mice suffer from seizures, a phenotype consistent with excessive hippocampal network activity. Loss of syndapin I causes defects in presynaptic membrane trafficking processes, which are especially evident under high-capacity retrieval conditions, accumulation of endocytic intermediates, loss of synaptic vesicle (SV) size control, impaired activity-dependent SV retrieval and defective synaptic activity. Detailed molecular analyses demonstrate that syndapin I plays an important role in the recruitment of all dynamin isoforms, central players in vesicle fission reactions, to the membrane. Consistently, syndapin I KO mice share phenotypes with dynamin I KO mice, whereas their seizure phenotype is very reminiscent of fitful mice expressing a mutant dynamin. Thus, syndapin I acts as pivotal membrane anchoring factor for dynamins during regeneration of SVs."xsd:string |
| http://purl.uniprot.org/citations/21926968 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2011.339"xsd:string |
| http://purl.uniprot.org/citations/21926968 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2011.339"xsd:string |
| http://purl.uniprot.org/citations/21926968 | http://purl.uniprot.org/core/author | "Sinning A."xsd:string |
| http://purl.uniprot.org/citations/21926968 | http://purl.uniprot.org/core/author | "Sinning A."xsd:string |
| http://purl.uniprot.org/citations/21926968 | http://purl.uniprot.org/core/author | "Muller A."xsd:string |
| http://purl.uniprot.org/citations/21926968 | http://purl.uniprot.org/core/author | "Muller A."xsd:string |
| http://purl.uniprot.org/citations/21926968 | http://purl.uniprot.org/core/author | "Boeckers T.M."xsd:string |
| http://purl.uniprot.org/citations/21926968 | http://purl.uniprot.org/core/author | "Boeckers T.M."xsd:string |
| http://purl.uniprot.org/citations/21926968 | http://purl.uniprot.org/core/author | "Moser M."xsd:string |
| http://purl.uniprot.org/citations/21926968 | http://purl.uniprot.org/core/author | "Moser M."xsd:string |
| http://purl.uniprot.org/citations/21926968 | http://purl.uniprot.org/core/author | "Ahmed T."xsd:string |
| http://purl.uniprot.org/citations/21926968 | http://purl.uniprot.org/core/author | "Ahmed T."xsd:string |
| http://purl.uniprot.org/citations/21926968 | http://purl.uniprot.org/core/author | "Grimm J."xsd:string |
| http://purl.uniprot.org/citations/21926968 | http://purl.uniprot.org/core/author | "Grimm J."xsd:string |
| http://purl.uniprot.org/citations/21926968 | http://purl.uniprot.org/core/author | "Fassler R."xsd:string |
| http://purl.uniprot.org/citations/21926968 | http://purl.uniprot.org/core/author | "Fassler R."xsd:string |
| http://purl.uniprot.org/citations/21926968 | http://purl.uniprot.org/core/author | "Hubner C.A."xsd:string |
| http://purl.uniprot.org/citations/21926968 | http://purl.uniprot.org/core/author | "Hubner C.A."xsd:string |
| http://purl.uniprot.org/citations/21926968 | http://purl.uniprot.org/core/author | "Koch D."xsd:string |
| http://purl.uniprot.org/citations/21926968 | http://purl.uniprot.org/core/author | "Koch D."xsd:string |
| http://purl.uniprot.org/citations/21926968 | http://purl.uniprot.org/core/author | "Balschun D."xsd:string |
| http://purl.uniprot.org/citations/21926968 | http://purl.uniprot.org/core/author | "Balschun D."xsd:string |