| http://purl.uniprot.org/citations/21926988 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21926988 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21926988 | http://www.w3.org/2000/01/rdf-schema#comment | "Anti-apoptotic Bcl2 family proteins such as Bcl-x(L) protect cells from death by sequestering apoptotic molecules, but also contribute to normal neuronal function. We find in hippocampal neurons that Bcl-x(L) enhances the efficiency of energy metabolism. Our evidence indicates that Bcl-x(L)interacts directly with the β-subunit of the F(1)F(O) ATP synthase, decreasing an ion leak within the F(1)F(O) ATPase complex and thereby increasing net transport of H(+) by F(1)F(O) during F(1)F(O) ATPase activity. By patch clamping submitochondrial vesicles enriched in F(1)F(O) ATP synthase complexes, we find that, in the presence of ATP, pharmacological or genetic inhibition of Bcl-x(L) activity increases the membrane leak conductance. In addition, recombinant Bcl-x(L) protein directly increases the level of ATPase activity of purified synthase complexes, and inhibition of endogenous Bcl-x(L) decreases the level of F(1)F(O) enzymatic activity. Our findings indicate that increased mitochondrial efficiency contributes to the enhanced synaptic efficacy found in Bcl-x(L)-expressing neurons."xsd:string |
| http://purl.uniprot.org/citations/21926988 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb2330"xsd:string |
| http://purl.uniprot.org/citations/21926988 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb2330"xsd:string |
| http://purl.uniprot.org/citations/21926988 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/21926988 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/21926988 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/21926988 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/21926988 | http://purl.uniprot.org/core/author | "Hardwick J.M."xsd:string |
| http://purl.uniprot.org/citations/21926988 | http://purl.uniprot.org/core/author | "Hardwick J.M."xsd:string |
| http://purl.uniprot.org/citations/21926988 | http://purl.uniprot.org/core/author | "Zeng L."xsd:string |
| http://purl.uniprot.org/citations/21926988 | http://purl.uniprot.org/core/author | "Zeng L."xsd:string |
| http://purl.uniprot.org/citations/21926988 | http://purl.uniprot.org/core/author | "Shore G.C."xsd:string |
| http://purl.uniprot.org/citations/21926988 | http://purl.uniprot.org/core/author | "Shore G.C."xsd:string |
| http://purl.uniprot.org/citations/21926988 | http://purl.uniprot.org/core/author | "Graham M."xsd:string |
| http://purl.uniprot.org/citations/21926988 | http://purl.uniprot.org/core/author | "Graham M."xsd:string |
| http://purl.uniprot.org/citations/21926988 | http://purl.uniprot.org/core/author | "Smith P.J."xsd:string |
| http://purl.uniprot.org/citations/21926988 | http://purl.uniprot.org/core/author | "Smith P.J."xsd:string |
| http://purl.uniprot.org/citations/21926988 | http://purl.uniprot.org/core/author | "Rahner C."xsd:string |
| http://purl.uniprot.org/citations/21926988 | http://purl.uniprot.org/core/author | "Rahner C."xsd:string |
| http://purl.uniprot.org/citations/21926988 | http://purl.uniprot.org/core/author | "Alavian K.N."xsd:string |
| http://purl.uniprot.org/citations/21926988 | http://purl.uniprot.org/core/author | "Alavian K.N."xsd:string |
| http://purl.uniprot.org/citations/21926988 | http://purl.uniprot.org/core/author | "Bonanni L."xsd:string |
| http://purl.uniprot.org/citations/21926988 | http://purl.uniprot.org/core/author | "Bonanni L."xsd:string |