| http://purl.uniprot.org/citations/21927000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21927000 | http://www.w3.org/2000/01/rdf-schema#comment | "Dynamin is a mechanochemical GTPase that oligomerizes around the neck of clathrin-coated pits and catalyses vesicle scission in a GTP-hydrolysis-dependent manner. The molecular details of oligomerization and the mechanism of the mechanochemical coupling are currently unknown. Here we present the crystal structure of human dynamin 1 in the nucleotide-free state with a four-domain architecture comprising the GTPase domain, the bundle signalling element, the stalk and the pleckstrin homology domain. Dynamin 1 oligomerized in the crystals via the stalks, which assemble in a criss-cross fashion. The stalks further interact via conserved surfaces with the pleckstrin homology domain and the bundle signalling element of the neighbouring dynamin molecule. This intricate domain interaction rationalizes a number of disease-related mutations in dynamin 2 and suggests a structural model for the mechanochemical coupling that reconciles previous models of dynamin function."xsd:string |
| http://purl.uniprot.org/citations/21927000 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature10369"xsd:string |
| http://purl.uniprot.org/citations/21927000 | http://purl.uniprot.org/core/author | "Gao S."xsd:string |
| http://purl.uniprot.org/citations/21927000 | http://purl.uniprot.org/core/author | "Daumke O."xsd:string |
| http://purl.uniprot.org/citations/21927000 | http://purl.uniprot.org/core/author | "Held M."xsd:string |
| http://purl.uniprot.org/citations/21927000 | http://purl.uniprot.org/core/author | "Roske Y."xsd:string |
| http://purl.uniprot.org/citations/21927000 | http://purl.uniprot.org/core/author | "Haucke V."xsd:string |
| http://purl.uniprot.org/citations/21927000 | http://purl.uniprot.org/core/author | "Faelber K."xsd:string |
| http://purl.uniprot.org/citations/21927000 | http://purl.uniprot.org/core/author | "Schulze D."xsd:string |
| http://purl.uniprot.org/citations/21927000 | http://purl.uniprot.org/core/author | "Noe F."xsd:string |
| http://purl.uniprot.org/citations/21927000 | http://purl.uniprot.org/core/author | "Posor Y."xsd:string |
| http://purl.uniprot.org/citations/21927000 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21927000 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/21927000 | http://purl.uniprot.org/core/pages | "556-560"xsd:string |
| http://purl.uniprot.org/citations/21927000 | http://purl.uniprot.org/core/title | "Crystal structure of nucleotide-free dynamin."xsd:string |
| http://purl.uniprot.org/citations/21927000 | http://purl.uniprot.org/core/volume | "477"xsd:string |
| http://purl.uniprot.org/citations/21927000 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21927000 |
| http://purl.uniprot.org/citations/21927000 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21927000 |
| http://purl.uniprot.org/uniprot/Q05193#attribution-2437CE102D4849280FE7DA5859C7344D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21927000 |
| http://purl.uniprot.org/uniprot/#_P63010-mappedCitation-21927000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21927000 |
| http://purl.uniprot.org/uniprot/#_P63027-mappedCitation-21927000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21927000 |
| http://purl.uniprot.org/uniprot/#_Q14247-mappedCitation-21927000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21927000 |
| http://purl.uniprot.org/uniprot/#_Q15642-mappedCitation-21927000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21927000 |
| http://purl.uniprot.org/uniprot/#_B3KU80-mappedCitation-21927000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21927000 |