| http://purl.uniprot.org/citations/21930779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21930779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21930779 | http://www.w3.org/2000/01/rdf-schema#comment | "In this report, we employed a lentiviral RNA interference screen to discover nucleolar DEAD/DEAH-box helicases involved in RNA polymerase I (Pol I)-mediated transcriptional activity. Our screen identified DHX33 as an important modulator of 47S rRNA transcription. We show that DHX33 is a cell cycle-regulated nucleolar protein that associates with ribosomal DNA (rDNA) loci, where it interacts with the RNA Pol I transcription factor upstream binding factor (UBF). DHX33 knockdown decreased the association of Pol I with rDNA and caused a dramatic decrease in levels of rRNA synthesis. Wild-type DHX33 overexpression, but not a DNA binding-defective mutant, enhanced 47S rRNA synthesis by promoting the association of RNA polymerase I with rDNA loci. In addition, an NTPase-defective DHX33 mutant (K94R) acted as a dominant negative mutant, inhibiting endogenous rRNA synthesis. Moreover, DHX33 deficiency in primary human fibroblasts triggered a nucleolar p53 stress response, resulting in an attenuation of proliferation. Thus, we show the mechanistic importance of DHX33 in rRNA transcription and proliferation."xsd:string |
| http://purl.uniprot.org/citations/21930779 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.05832-11"xsd:string |
| http://purl.uniprot.org/citations/21930779 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.05832-11"xsd:string |
| http://purl.uniprot.org/citations/21930779 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/21930779 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/21930779 | http://purl.uniprot.org/core/author | "Weber J.D."xsd:string |
| http://purl.uniprot.org/citations/21930779 | http://purl.uniprot.org/core/author | "Weber J.D."xsd:string |
| http://purl.uniprot.org/citations/21930779 | http://purl.uniprot.org/core/author | "Forys J.T."xsd:string |
| http://purl.uniprot.org/citations/21930779 | http://purl.uniprot.org/core/author | "Forys J.T."xsd:string |
| http://purl.uniprot.org/citations/21930779 | http://purl.uniprot.org/core/author | "Gwinn A.S."xsd:string |
| http://purl.uniprot.org/citations/21930779 | http://purl.uniprot.org/core/author | "Gwinn A.S."xsd:string |
| http://purl.uniprot.org/citations/21930779 | http://purl.uniprot.org/core/author | "Miceli A.P."xsd:string |
| http://purl.uniprot.org/citations/21930779 | http://purl.uniprot.org/core/author | "Miceli A.P."xsd:string |
| http://purl.uniprot.org/citations/21930779 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21930779 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21930779 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/21930779 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/21930779 | http://purl.uniprot.org/core/pages | "4676-4691"xsd:string |
| http://purl.uniprot.org/citations/21930779 | http://purl.uniprot.org/core/pages | "4676-4691"xsd:string |
| http://purl.uniprot.org/citations/21930779 | http://purl.uniprot.org/core/title | "Identification of DHX33 as a mediator of rRNA synthesis and cell growth."xsd:string |
| http://purl.uniprot.org/citations/21930779 | http://purl.uniprot.org/core/title | "Identification of DHX33 as a mediator of rRNA synthesis and cell growth."xsd:string |
| http://purl.uniprot.org/citations/21930779 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/21930779 | http://purl.uniprot.org/core/volume | "31"xsd:string |