| http://purl.uniprot.org/citations/21930782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21930782 | http://www.w3.org/2000/01/rdf-schema#comment | "The transcription factor Gata-3 is a definitive marker of luminal breast cancers and a key regulator of mammary morphogenesis. Here we have explored a role for Gata-3 in tumor initiation and the underlying cellular mechanisms using a mouse model of "luminal-like" cancer. Loss of a single Gata-3 allele markedly accelerated tumor progression in mice carrying the mouse mammary tumor virus promoter-driven polyomavirus middle T antigen (MMTV-PyMT mice), while overexpression of Gata-3 curtailed tumorigenesis. Through the identification of two distinct luminal progenitor cells in the mammary gland, we demonstrate that Gata-3 haplo-insufficiency increases the tumor-initiating capacity of these progenitors but not the stem cell-enriched population. Overexpression of a conditional Gata-3 transgene in the PyMT model promoted cellular differentiation and led to reduced tumor-initiating capacity as well as diminished angiogenesis. Transcript profiling studies identified caspase-14 as a novel downstream target of Gata-3, in keeping with its roles in differentiation and tumorigenesis. A strong association was evident between GATA-3 and caspase-14 expression in preinvasive ductal carcinoma in situ samples, where GATA-3 also displayed prognostic significance. Overall, these studies identify GATA-3 as an important regulator of tumor initiation through its ability to promote the differentiation of committed luminal progenitor cells."xsd:string |
| http://purl.uniprot.org/citations/21930782 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.05766-11"xsd:string |
| http://purl.uniprot.org/citations/21930782 | http://purl.uniprot.org/core/author | "Holroyd S."xsd:string |
| http://purl.uniprot.org/citations/21930782 | http://purl.uniprot.org/core/author | "Wu D."xsd:string |
| http://purl.uniprot.org/citations/21930782 | http://purl.uniprot.org/core/author | "Shi W."xsd:string |
| http://purl.uniprot.org/citations/21930782 | http://purl.uniprot.org/core/author | "Smyth G.K."xsd:string |
| http://purl.uniprot.org/citations/21930782 | http://purl.uniprot.org/core/author | "Deb S."xsd:string |
| http://purl.uniprot.org/citations/21930782 | http://purl.uniprot.org/core/author | "Lindeman G.J."xsd:string |
| http://purl.uniprot.org/citations/21930782 | http://purl.uniprot.org/core/author | "Visvader J.E."xsd:string |
| http://purl.uniprot.org/citations/21930782 | http://purl.uniprot.org/core/author | "Ward T."xsd:string |
| http://purl.uniprot.org/citations/21930782 | http://purl.uniprot.org/core/author | "Fox S.B."xsd:string |
| http://purl.uniprot.org/citations/21930782 | http://purl.uniprot.org/core/author | "Bath M.L."xsd:string |
| http://purl.uniprot.org/citations/21930782 | http://purl.uniprot.org/core/author | "Breslin K."xsd:string |
| http://purl.uniprot.org/citations/21930782 | http://purl.uniprot.org/core/author | "Vaillant F."xsd:string |
| http://purl.uniprot.org/citations/21930782 | http://purl.uniprot.org/core/author | "Sutherland K.D."xsd:string |
| http://purl.uniprot.org/citations/21930782 | http://purl.uniprot.org/core/author | "Asselin-Labat M.L."xsd:string |
| http://purl.uniprot.org/citations/21930782 | http://purl.uniprot.org/core/author | "Gyorki D.E."xsd:string |
| http://purl.uniprot.org/citations/21930782 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21930782 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/21930782 | http://purl.uniprot.org/core/pages | "4609-4622"xsd:string |
| http://purl.uniprot.org/citations/21930782 | http://purl.uniprot.org/core/title | "Gata-3 negatively regulates the tumor-initiating capacity of mammary luminal progenitor cells and targets the putative tumor suppressor caspase-14."xsd:string |
| http://purl.uniprot.org/citations/21930782 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/21930782 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21930782 |
| http://purl.uniprot.org/citations/21930782 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21930782 |