| http://purl.uniprot.org/citations/21930792 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21930792 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21930792 | http://www.w3.org/2000/01/rdf-schema#comment | "Formation of the immunological synapse between an antigen-presenting cell (APC) and a T cell leads to signal generation in both cells involved. In T cells, the lipid raft-associated transmembrane adaptor protein LAT plays a central role. Its phosphorylation is a crucial step in signal propagation, including the calcium response and mitogen-activated protein kinase activation, and largely depends on its association with the SLP76 adaptor protein. Here we report the discovery of a new palmitoylated transmembrane adaptor protein, termed SCIMP. SCIMP is expressed in B cells and other professional APCs and is localized in the immunological synapse due to its association with tetraspanin-enriched microdomains. In B cells, it is constitutively associated with Lyn kinase and becomes tyrosine phosphorylated after major histocompatibility complex type II (MHC-II) stimulation. When phosphorylated, SCIMP binds to the SLP65 adaptor protein and also to the inhibitory kinase Csk. While the association with SLP65 initiates the downstream signaling cascades, Csk binding functions as a negative regulatory loop. The results suggest that SCIMP is involved in signal transduction after MHC-II stimulation and therefore serves as a regulator of antigen presentation and other APC functions."xsd:string |
| http://purl.uniprot.org/citations/21930792 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.05817-11"xsd:string |
| http://purl.uniprot.org/citations/21930792 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.05817-11"xsd:string |
| http://purl.uniprot.org/citations/21930792 | http://purl.uniprot.org/core/author | "Draber P."xsd:string |
| http://purl.uniprot.org/citations/21930792 | http://purl.uniprot.org/core/author | "Draber P."xsd:string |
| http://purl.uniprot.org/citations/21930792 | http://purl.uniprot.org/core/author | "Yeung M."xsd:string |
| http://purl.uniprot.org/citations/21930792 | http://purl.uniprot.org/core/author | "Yeung M."xsd:string |
| http://purl.uniprot.org/citations/21930792 | http://purl.uniprot.org/core/author | "Weiss A."xsd:string |
| http://purl.uniprot.org/citations/21930792 | http://purl.uniprot.org/core/author | "Weiss A."xsd:string |
| http://purl.uniprot.org/citations/21930792 | http://purl.uniprot.org/core/author | "Vonkova I."xsd:string |
| http://purl.uniprot.org/citations/21930792 | http://purl.uniprot.org/core/author | "Vonkova I."xsd:string |
| http://purl.uniprot.org/citations/21930792 | http://purl.uniprot.org/core/author | "Angelisova P."xsd:string |
| http://purl.uniprot.org/citations/21930792 | http://purl.uniprot.org/core/author | "Angelisova P."xsd:string |
| http://purl.uniprot.org/citations/21930792 | http://purl.uniprot.org/core/author | "Brdicka T."xsd:string |
| http://purl.uniprot.org/citations/21930792 | http://purl.uniprot.org/core/author | "Brdicka T."xsd:string |
| http://purl.uniprot.org/citations/21930792 | http://purl.uniprot.org/core/author | "Horejsi V."xsd:string |
| http://purl.uniprot.org/citations/21930792 | http://purl.uniprot.org/core/author | "Horejsi V."xsd:string |
| http://purl.uniprot.org/citations/21930792 | http://purl.uniprot.org/core/author | "Hrdinka M."xsd:string |
| http://purl.uniprot.org/citations/21930792 | http://purl.uniprot.org/core/author | "Hrdinka M."xsd:string |
| http://purl.uniprot.org/citations/21930792 | http://purl.uniprot.org/core/author | "Kucova M."xsd:string |
| http://purl.uniprot.org/citations/21930792 | http://purl.uniprot.org/core/author | "Kucova M."xsd:string |
| http://purl.uniprot.org/citations/21930792 | http://purl.uniprot.org/core/author | "Otahal P."xsd:string |
| http://purl.uniprot.org/citations/21930792 | http://purl.uniprot.org/core/author | "Otahal P."xsd:string |