| http://purl.uniprot.org/citations/21931670 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21931670 | http://www.w3.org/2000/01/rdf-schema#comment | "The availability of sequence specificities for a substantial fraction of yeast's transcription factors and comparative genomic algorithms for binding site prediction has made it possible to comprehensively annotate transcription factor binding sites genome-wide. Here we use such a genome-wide annotation for comprehensively studying promoter architecture in yeast, focusing on the distribution of transcription factor binding sites relative to transcription start sites, and the architecture of TATA and TATA-less promoters. For most transcription factors, binding sites are positioned further upstream and vary over a wider range in TATA promoters than in TATA-less promoters. In contrast, a group of 6 'proximal promoter motifs' (GAT1/GLN3/DAL80, FKH1/2, PBF1/2, RPN4, NDT80, and ROX1) occur preferentially in TATA-less promoters and show a strong preference for binding close to the transcription start site in these promoters. We provide evidence that suggests that pre-initiation complexes are recruited at TATA sites in TATA promoters and at the sites of the other proximal promoter motifs in TATA-less promoters. TATA-less promoters can generally be classified by the proximal promoter motif they contain, with different classes of TATA-less promoters showing different patterns of transcription factor binding site positioning and nucleosome coverage. These observations suggest that different modes of regulation of transcription initiation may be operating in the different promoter classes. In addition we show that, across all promoter classes, there is a close match between nucleosome free regions and regions of highest transcription factor binding site density. This close agreement between transcription factor binding site density and nucleosome depletion suggests a direct and general competition between transcription factors and nucleosomes for binding to promoters."xsd:string |
| http://purl.uniprot.org/citations/21931670 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0024279"xsd:string |
| http://purl.uniprot.org/citations/21931670 | http://purl.uniprot.org/core/author | "van Nimwegen E."xsd:string |
| http://purl.uniprot.org/citations/21931670 | http://purl.uniprot.org/core/author | "Erb I."xsd:string |
| http://purl.uniprot.org/citations/21931670 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21931670 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/21931670 | http://purl.uniprot.org/core/pages | "e24279"xsd:string |
| http://purl.uniprot.org/citations/21931670 | http://purl.uniprot.org/core/title | "Transcription factor binding site positioning in yeast: proximal promoter motifs characterize TATA-less promoters."xsd:string |
| http://purl.uniprot.org/citations/21931670 | http://purl.uniprot.org/core/volume | "6"xsd:string |
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| http://purl.uniprot.org/uniprot/#_P33200-mappedCitation-21931670 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21931670 |