| http://purl.uniprot.org/citations/21931671 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21931671 | http://www.w3.org/2000/01/rdf-schema#comment | "Several epidemiological studies have correlated the use of non-steroidal anti-inflammatory drugs (NSAID) with reduced risk of ovarian cancer, the most lethal gynecological cancer, diagnosed usually in late stages of the disease. We have previously established that the pro-apoptotic cytokine melanoma differentiation associated gene-7/Interleukin-24 (mda-7/IL-24) is a crucial mediator of NSAID-induced apoptosis in prostate, breast, renal and stomach cancer cells. In this report we evaluated various structurally different NSAIDs for their efficacies to induce apoptosis and mda-7/IL-24 expression in ovarian cancer cells. While several NSAIDs induced apoptosis, Sulindac Sulfide and Diclofenac most potently induced apoptosis and reduced tumor growth. A combination of these agents results in a synergistic effect. Furthermore, mda-7/IL-24 induction by NSAIDs is essential for programmed cell death, since inhibition of mda-7/IL-24 by small interfering RNA abrogates apoptosis. mda-7/IL-24 activation leads to upregulation of growth arrest and DNA damage inducible (GADD) 45 α and γ and JNK activation. The NF-κB family of transcription factors has been implicated in ovarian cancer development. We previously established NF-κB/IκB signaling as an essential step for cell survival in cancer cells and hypothesized that targeting NF-κB could potentiate NSAID-mediated apoptosis induction in ovarian cancer cells. Indeed, combining NSAID treatment with NF-κB inhibitors led to enhanced apoptosis induction. Our results indicate that inhibition of NF-κB in combination with activation of mda-7/IL-24 expression may lead to a new combinatorial therapy for ovarian cancer."xsd:string |
| http://purl.uniprot.org/citations/21931671 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0024285"xsd:string |
| http://purl.uniprot.org/citations/21931671 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/21931671 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/21931671 | http://purl.uniprot.org/core/author | "Tamura R.E."xsd:string |
| http://purl.uniprot.org/citations/21931671 | http://purl.uniprot.org/core/author | "Gu X."xsd:string |
| http://purl.uniprot.org/citations/21931671 | http://purl.uniprot.org/core/author | "Simabuco F.M."xsd:string |
| http://purl.uniprot.org/citations/21931671 | http://purl.uniprot.org/core/author | "Libermann T.A."xsd:string |
| http://purl.uniprot.org/citations/21931671 | http://purl.uniprot.org/core/author | "Fisher P.B."xsd:string |
| http://purl.uniprot.org/citations/21931671 | http://purl.uniprot.org/core/author | "Correa R.G."xsd:string |
| http://purl.uniprot.org/citations/21931671 | http://purl.uniprot.org/core/author | "Sarkar D."xsd:string |
| http://purl.uniprot.org/citations/21931671 | http://purl.uniprot.org/core/author | "Bhasin M."xsd:string |
| http://purl.uniprot.org/citations/21931671 | http://purl.uniprot.org/core/author | "Zerbini L.F."xsd:string |
| http://purl.uniprot.org/citations/21931671 | http://purl.uniprot.org/core/author | "Cordeiro J."xsd:string |
| http://purl.uniprot.org/citations/21931671 | http://purl.uniprot.org/core/author | "Czibere A."xsd:string |
| http://purl.uniprot.org/citations/21931671 | http://purl.uniprot.org/core/author | "Zhou J.R."xsd:string |
| http://purl.uniprot.org/citations/21931671 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21931671 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/21931671 | http://purl.uniprot.org/core/pages | "e24285"xsd:string |
| http://purl.uniprot.org/citations/21931671 | http://purl.uniprot.org/core/title | "Combinatorial effect of non-steroidal anti-inflammatory drugs and NF-kappaB inhibitors in ovarian cancer therapy."xsd:string |
| http://purl.uniprot.org/citations/21931671 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/21931671 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21931671 |
| http://purl.uniprot.org/citations/21931671 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21931671 |
| http://purl.uniprot.org/uniprot/#_A5JUZ3-mappedCitation-21931671 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21931671 |