| http://purl.uniprot.org/citations/21934106 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21934106 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumor cells can co-opt the promigratory activity of chemokines and their cognate G protein-coupled receptors (GPCRs) to metastasize to regional lymph nodes or distant organs. Indeed, the migration toward SDF-1 (stromal cell-derived factor 1) of tumor cells bearing CXCR4 [chemokine (C-X-C motif) receptor 4] has been implicated in the lymphatic and organ-specific metastasis of various human malignancies. Here, we used chimeric G proteins and GPCRs activated solely by artificial ligands to selectively activate the signaling pathways downstream of specific G proteins and showed that CXCR4-mediated chemotaxis and transendothelial migration of metastatic basal-like breast cancer cells required activation of Gα(13), a member of the Gα(12/13) G protein family, and of the small guanosine triphosphatase Rho. Multiple complementary experimental strategies, including synthetic biology approaches, indicated that signaling-selective inhibition of the CXCR4-Gα(13)-Rho axis prevents the metastatic spread of basal-like breast cancer cells."xsd:string |
| http://purl.uniprot.org/citations/21934106 | http://purl.org/dc/terms/identifier | "doi:10.1126/scisignal.2002221"xsd:string |
| http://purl.uniprot.org/citations/21934106 | http://purl.uniprot.org/core/author | "Bouvier M."xsd:string |
| http://purl.uniprot.org/citations/21934106 | http://purl.uniprot.org/core/author | "Gutkind J.S."xsd:string |
| http://purl.uniprot.org/citations/21934106 | http://purl.uniprot.org/core/author | "Yagi H."xsd:string |
| http://purl.uniprot.org/citations/21934106 | http://purl.uniprot.org/core/author | "Tan W."xsd:string |
| http://purl.uniprot.org/citations/21934106 | http://purl.uniprot.org/core/author | "Simaan M."xsd:string |
| http://purl.uniprot.org/citations/21934106 | http://purl.uniprot.org/core/author | "Armando S."xsd:string |
| http://purl.uniprot.org/citations/21934106 | http://purl.uniprot.org/core/author | "Molinolo A.A."xsd:string |
| http://purl.uniprot.org/citations/21934106 | http://purl.uniprot.org/core/author | "Weigert R."xsd:string |
| http://purl.uniprot.org/citations/21934106 | http://purl.uniprot.org/core/author | "Amornphimoltham P."xsd:string |
| http://purl.uniprot.org/citations/21934106 | http://purl.uniprot.org/core/author | "Dillenburg-Pilla P."xsd:string |
| http://purl.uniprot.org/citations/21934106 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21934106 | http://purl.uniprot.org/core/name | "Sci Signal"xsd:string |
| http://purl.uniprot.org/citations/21934106 | http://purl.uniprot.org/core/pages | "ra60"xsd:string |
| http://purl.uniprot.org/citations/21934106 | http://purl.uniprot.org/core/title | "A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cells."xsd:string |
| http://purl.uniprot.org/citations/21934106 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/21934106 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21934106 |
| http://purl.uniprot.org/citations/21934106 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21934106 |
| http://purl.uniprot.org/uniprot/#_A0A0U3FJG0-mappedCitation-21934106 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21934106 |
| http://purl.uniprot.org/uniprot/#_A0A0U3GXA9-mappedCitation-21934106 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21934106 |
| http://purl.uniprot.org/uniprot/#_A0A8Q3WLL1-mappedCitation-21934106 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21934106 |
| http://purl.uniprot.org/uniprot/#_B4DWV9-mappedCitation-21934106 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21934106 |
| http://purl.uniprot.org/uniprot/#_Q14344-mappedCitation-21934106 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21934106 |