| http://purl.uniprot.org/citations/21936715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21936715 | http://www.w3.org/2000/01/rdf-schema#comment | "Rho GTPases are able to influence the replication of human immunodeficiency virus type 1 (HIV-1). However, little is known about the regulation of HIV-1 replication by guanine nucleotide dissociation inhibitors (GDIs), one of the three major regulators of the Rho GTPase activation cycle. From a T cell-based cDNA library screening, ARHGDIB/RhoGDIβ, a hematopoietic lineage-specific GDI family protein, was identified as a negative regulator of HIV-1 replication. Up-regulation of ARHGDIB attenuated the replication of HIV-1 in multiple T cell lines. The results showed that (1) a significant portion of RhoA and Rac1, but not Cdc42, exists in the GTP-bound active form under steady-state conditions, (2) ectopic ARHGDIB expression reduced the F-actin content and the active forms of both RhoA and Rac1, and (3) HIV-1 infection was attenuated by either ectopic expression of ARHGDIB or inhibition of the RhoA signal cascade at the HIV-1 Env-dependent early phase of the viral life cycle. This is in good agreement with the previous finding that RhoA and Rac1 promote HIV-1 entry by increasing the efficiency of receptor clustering and virus-cell membrane fusion. In conclusion, the ARHGDIB is a lymphoid-specific intrinsic negative regulator of HIV-1 replication that acts by simultaneously inhibiting RhoA and Rac1 functions."xsd:string |
| http://purl.uniprot.org/citations/21936715 | http://purl.org/dc/terms/identifier | "doi:10.1089/aid.2011.0180"xsd:string |
| http://purl.uniprot.org/citations/21936715 | http://purl.uniprot.org/core/author | "Koyanagi Y."xsd:string |
| http://purl.uniprot.org/citations/21936715 | http://purl.uniprot.org/core/author | "Miyauchi K."xsd:string |
| http://purl.uniprot.org/citations/21936715 | http://purl.uniprot.org/core/author | "Sato K."xsd:string |
| http://purl.uniprot.org/citations/21936715 | http://purl.uniprot.org/core/author | "Watanabe T."xsd:string |
| http://purl.uniprot.org/citations/21936715 | http://purl.uniprot.org/core/author | "Misawa N."xsd:string |
| http://purl.uniprot.org/citations/21936715 | http://purl.uniprot.org/core/author | "Ebina H."xsd:string |
| http://purl.uniprot.org/citations/21936715 | http://purl.uniprot.org/core/author | "Ichikawa R."xsd:string |
| http://purl.uniprot.org/citations/21936715 | http://purl.uniprot.org/core/author | "Komano J."xsd:string |
| http://purl.uniprot.org/citations/21936715 | http://purl.uniprot.org/core/author | "Urano E."xsd:string |
| http://purl.uniprot.org/citations/21936715 | http://purl.uniprot.org/core/author | "Hamatake M."xsd:string |
| http://purl.uniprot.org/citations/21936715 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/21936715 | http://purl.uniprot.org/core/name | "AIDS Res Hum Retroviruses"xsd:string |
| http://purl.uniprot.org/citations/21936715 | http://purl.uniprot.org/core/pages | "913-922"xsd:string |
| http://purl.uniprot.org/citations/21936715 | http://purl.uniprot.org/core/title | "The hematopoietic cell-specific Rho GTPase inhibitor ARHGDIB/D4GDI limits HIV type 1 replication."xsd:string |
| http://purl.uniprot.org/citations/21936715 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/21936715 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21936715 |
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| http://purl.uniprot.org/uniprot/P52565 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21936715 |