| http://purl.uniprot.org/citations/21937440 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21937440 | http://www.w3.org/2000/01/rdf-schema#comment | "The cytokines oncostatin M (OSM) and IL-6 promote breast cancer cell migration and metastasis. Both cytokines activate STAT3, a member of the STAT (signal transducers and activators of transcription) family of transcription factors. Through transcriptional regulation of its target genes, STAT3 controls a wide range of cellular processes, including cellular proliferation, oncogenesis, and cancer metastasis. Fascin is an actin-bundling protein involved in cell migration. Elevated levels of fascin expression are found in many metastatic cancers, and inhibition of fascin function by small chemical compounds leads to a block of tumor metastasis. In this work, we demonstrate that fascin is a direct STAT3 target gene in response to OSM and IL-6 in both mouse and human breast cancer cells. We show that NFκB also binds to the fascin promoter in response to cytokine treatment and this binding is STAT3-dependent. Both STAT3 and NFκB are required for the cytokine-induced expression of fascin in cancer cells. Furthermore, we demonstrate that STAT3, in directly controlling fascin expression, is both necessary and sufficient for breast cancer cell migration."xsd:string |
| http://purl.uniprot.org/citations/21937440 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m111.286245"xsd:string |
| http://purl.uniprot.org/citations/21937440 | http://purl.uniprot.org/core/author | "Snyder M."xsd:string |
| http://purl.uniprot.org/citations/21937440 | http://purl.uniprot.org/core/author | "Zhang J.J."xsd:string |
| http://purl.uniprot.org/citations/21937440 | http://purl.uniprot.org/core/author | "Huang X.Y."xsd:string |
| http://purl.uniprot.org/citations/21937440 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21937440 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/21937440 | http://purl.uniprot.org/core/pages | "38886-38893"xsd:string |
| http://purl.uniprot.org/citations/21937440 | http://purl.uniprot.org/core/title | "Signal transducers and activators of transcription 3 (STAT3) directly regulates cytokine-induced fascin expression and is required for breast cancer cell migration."xsd:string |
| http://purl.uniprot.org/citations/21937440 | http://purl.uniprot.org/core/volume | "286"xsd:string |
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| http://purl.uniprot.org/uniprot/#_B4DNP0-mappedCitation-21937440 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21937440 |
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| http://purl.uniprot.org/uniprot/#_Q15306-mappedCitation-21937440 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21937440 |