| http://purl.uniprot.org/citations/21937600 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21937600 | http://www.w3.org/2000/01/rdf-schema#comment | "Correct development of the cerebellum requires coordinated sonic hedgehog (Shh) signaling from Purkinje to granule cells. How Shh expression is regulated in Purkinje cells is poorly understood. Using a novel tyrosinase minigene-tagged Sleeping Beauty transposon-mediated mutagenesis, which allows for coat color-based genotyping, we created mice in which the Ski/Sno family transcriptional co-repressor 2 (Skor2) gene is deleted. Loss of Skor2 leads to defective Purkinje cell development, a severe reduction of granule cell proliferation and a malformed cerebellum. Skor2 is specifically expressed in Purkinje cells in the brain, where it is required for proper expression of Shh. Skor2 overexpression suppresses BMP signaling in an HDAC-dependent manner and stimulates Shh promoter activity, suggesting that Skor2 represses BMP signaling to activate Shh expression. Our study identifies an essential function for Skor2 as a novel transcriptional regulator in Purkinje cells that acts upstream of Shh during cerebellum development."xsd:string |
| http://purl.uniprot.org/citations/21937600 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.067264"xsd:string |
| http://purl.uniprot.org/citations/21937600 | http://purl.uniprot.org/core/author | "Wang B."xsd:string |
| http://purl.uniprot.org/citations/21937600 | http://purl.uniprot.org/core/author | "Zheng H."xsd:string |
| http://purl.uniprot.org/citations/21937600 | http://purl.uniprot.org/core/author | "Overbeek P.A."xsd:string |
| http://purl.uniprot.org/citations/21937600 | http://purl.uniprot.org/core/author | "Harrison W."xsd:string |
| http://purl.uniprot.org/citations/21937600 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21937600 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/21937600 | http://purl.uniprot.org/core/pages | "4487-4497"xsd:string |
| http://purl.uniprot.org/citations/21937600 | http://purl.uniprot.org/core/title | "Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development."xsd:string |
| http://purl.uniprot.org/citations/21937600 | http://purl.uniprot.org/core/volume | "138"xsd:string |
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