| http://purl.uniprot.org/citations/21940793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21940793 | http://www.w3.org/2000/01/rdf-schema#comment | "Linker histone H1 is a fundamental chromosomal protein involved in the maintenance of higher-ordered chromatin organization. The exchange dynamics of histone H1 correlates well with chromatin plasticity. A variety of core histone chaperones involved in core histone dynamics has been identified, but the identity of the linker histone chaperone in the somatic cell nucleus has been a long-standing unanswered question. Here we show that Template Activating Factor-I (TAF-I, also known as protein SET) is involved in histone H1 dynamics as a linker histone chaperone. Among previously identified core histone chaperones and linker histone chaperone candidates, only TAF-I was found to be associated specifically with histone H1 in mammalian somatic cell nuclei. TAF-I showed linker histone chaperone activity in vitro. Fluorescence recovery after photobleaching analyses revealed that TAF-I is involved in the regulation of histone H1 dynamics in the nucleus. Therefore, we propose that TAF-I is a key molecule that regulates linker histone-mediated chromatin assembly and disassembly."xsd:string |
| http://purl.uniprot.org/citations/21940793 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.083139"xsd:string |
| http://purl.uniprot.org/citations/21940793 | http://purl.uniprot.org/core/author | "Kato K."xsd:string |
| http://purl.uniprot.org/citations/21940793 | http://purl.uniprot.org/core/author | "Nagata K."xsd:string |
| http://purl.uniprot.org/citations/21940793 | http://purl.uniprot.org/core/author | "Okuwaki M."xsd:string |
| http://purl.uniprot.org/citations/21940793 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21940793 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/21940793 | http://purl.uniprot.org/core/pages | "3254-3265"xsd:string |
| http://purl.uniprot.org/citations/21940793 | http://purl.uniprot.org/core/title | "Role of Template Activating Factor-I as a chaperone in linker histone dynamics."xsd:string |
| http://purl.uniprot.org/citations/21940793 | http://purl.uniprot.org/core/volume | "124"xsd:string |
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