| http://purl.uniprot.org/citations/21940857 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21940857 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21940857 | http://www.w3.org/2000/01/rdf-schema#comment | "Although many eukaryotic proteins are amino (N)-terminally acetylated, structural mechanisms by which N-terminal acetylation mediates protein interactions are largely unknown. Here, we found that N-terminal acetylation of the E2 enzyme, Ubc12, dictates distinctive E3-dependent ligation of the ubiquitin-like protein Nedd8 to Cul1. Structural, biochemical, biophysical, and genetic analyses revealed how complete burial of Ubc12's N-acetyl-methionine in a hydrophobic pocket in the E3, Dcn1, promotes cullin neddylation. The results suggest that the N-terminal acetyl both directs Ubc12's interactions with Dcn1 and prevents repulsion of a charged N terminus. Our data provide a link between acetylation and ubiquitin-like protein conjugation and define a mechanism for N-terminal acetylation-dependent recognition."xsd:string |
| http://purl.uniprot.org/citations/21940857 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1209307"xsd:string |
| http://purl.uniprot.org/citations/21940857 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1209307"xsd:string |
| http://purl.uniprot.org/citations/21940857 | http://purl.uniprot.org/core/author | "Schulman B.A."xsd:string |
| http://purl.uniprot.org/citations/21940857 | http://purl.uniprot.org/core/author | "Schulman B.A."xsd:string |
| http://purl.uniprot.org/citations/21940857 | http://purl.uniprot.org/core/author | "Harper J.W."xsd:string |
| http://purl.uniprot.org/citations/21940857 | http://purl.uniprot.org/core/author | "Harper J.W."xsd:string |
| http://purl.uniprot.org/citations/21940857 | http://purl.uniprot.org/core/author | "Scott D.C."xsd:string |
| http://purl.uniprot.org/citations/21940857 | http://purl.uniprot.org/core/author | "Scott D.C."xsd:string |
| http://purl.uniprot.org/citations/21940857 | http://purl.uniprot.org/core/author | "Bennett E.J."xsd:string |
| http://purl.uniprot.org/citations/21940857 | http://purl.uniprot.org/core/author | "Bennett E.J."xsd:string |
| http://purl.uniprot.org/citations/21940857 | http://purl.uniprot.org/core/author | "Monda J.K."xsd:string |
| http://purl.uniprot.org/citations/21940857 | http://purl.uniprot.org/core/author | "Monda J.K."xsd:string |
| http://purl.uniprot.org/citations/21940857 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21940857 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21940857 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/21940857 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/21940857 | http://purl.uniprot.org/core/pages | "674-678"xsd:string |
| http://purl.uniprot.org/citations/21940857 | http://purl.uniprot.org/core/pages | "674-678"xsd:string |
| http://purl.uniprot.org/citations/21940857 | http://purl.uniprot.org/core/title | "N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex."xsd:string |
| http://purl.uniprot.org/citations/21940857 | http://purl.uniprot.org/core/title | "N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex."xsd:string |
| http://purl.uniprot.org/citations/21940857 | http://purl.uniprot.org/core/volume | "334"xsd:string |
| http://purl.uniprot.org/citations/21940857 | http://purl.uniprot.org/core/volume | "334"xsd:string |