| http://purl.uniprot.org/citations/21944272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21944272 | http://www.w3.org/2000/01/rdf-schema#comment | "The objective was to investigate circulating concentrations of bone formation markers (undercarboxylated osteocalcin [Glu-OC], an established marker of bone formation during fetal and early postnatal life], and Dickkopf-1 [DKK-1], a natural inhibitor of osteoblastogenesis during fetal development]) in intrauterine-growth-restricted (IUGR; associated with impaired fetal skeletal development) and appropriate-for-gestational-age (AGA) pregnancies. Circulating concentrations of Glu-OC and DKK-1 were determined by enzyme immunoassay in 40 mothers and their 20 asymmetric IUGR and 20 AGA singleton full-term fetuses and neonates on postnatal day 1 (N1) and 4 (N4). Parametric tests were applied in the statistical analysis. No significant differences in Glu-OC concentrations were observed between IUGR and AGA groups, whereas fetal DKK-1 concentrations were lower in the IUGR group (P = .028). In both groups, maternal Glu-OC and DKK-1 concentrations were lower than fetal, N1, and N4 concentrations (P ≤ .012 in all cases), whereas fetal Glu-OC concentrations were higher than N1 and N4 ones (P ≤ .037 in all cases). In addition, N1 Glu-OC concentrations were higher than N4 concentrations (P = .047). Finally, maternal Glu-OC and DKK-1 concentrations positively correlated with fetal, N1, and N4 ones (r ≥ 0.404, P ≤ .01 in all cases). Fetal/neonatal bone formation may not be impaired in full-term asymmetric IUGR infants, as indicated by the similar Glu-OC concentrations in both groups. Fetal DDK-1 concentrations are lower in the IUGR group, representing probably a compensatory mechanism, favoring the formation of mineralized bone. Fetal/neonatal bone turnover is markedly enhanced compared with maternal one and seems to be associated with the latter in both late pregnancy and early postpartum."xsd:string |
| http://purl.uniprot.org/citations/21944272 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.metabol.2011.07.008"xsd:string |
| http://purl.uniprot.org/citations/21944272 | http://purl.uniprot.org/core/author | "Gourgiotis D."xsd:string |
| http://purl.uniprot.org/citations/21944272 | http://purl.uniprot.org/core/author | "Georgiadis A."xsd:string |
| http://purl.uniprot.org/citations/21944272 | http://purl.uniprot.org/core/author | "Hassiakos D."xsd:string |
| http://purl.uniprot.org/citations/21944272 | http://purl.uniprot.org/core/author | "Malamitsi-Puchner A."xsd:string |
| http://purl.uniprot.org/citations/21944272 | http://purl.uniprot.org/core/author | "Baka S."xsd:string |
| http://purl.uniprot.org/citations/21944272 | http://purl.uniprot.org/core/author | "Boutsikou M."xsd:string |
| http://purl.uniprot.org/citations/21944272 | http://purl.uniprot.org/core/author | "Briana D.D."xsd:string |
| http://purl.uniprot.org/citations/21944272 | http://purl.uniprot.org/core/author | "Marmarinos A."xsd:string |
| http://purl.uniprot.org/citations/21944272 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/21944272 | http://purl.uniprot.org/core/name | "Metabolism"xsd:string |
| http://purl.uniprot.org/citations/21944272 | http://purl.uniprot.org/core/pages | "335-340"xsd:string |
| http://purl.uniprot.org/citations/21944272 | http://purl.uniprot.org/core/title | "Intrauterine growth restriction may not suppress bone formation at term, as indicated by circulating concentrations of undercarboxylated osteocalcin and Dickkopf-1."xsd:string |
| http://purl.uniprot.org/citations/21944272 | http://purl.uniprot.org/core/volume | "61"xsd:string |
| http://purl.uniprot.org/citations/21944272 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21944272 |
| http://purl.uniprot.org/citations/21944272 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21944272 |
| http://purl.uniprot.org/uniprot/#_I1W660-mappedCitation-21944272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21944272 |
| http://purl.uniprot.org/uniprot/#_O94907-mappedCitation-21944272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21944272 |
| http://purl.uniprot.org/uniprot/#_P02818-mappedCitation-21944272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21944272 |
| http://purl.uniprot.org/uniprot/I1W660 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21944272 |
| http://purl.uniprot.org/uniprot/O94907 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21944272 |
| http://purl.uniprot.org/uniprot/P02818 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21944272 |