| http://purl.uniprot.org/citations/21944720 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21944720 | http://www.w3.org/2000/01/rdf-schema#comment | "Cyclin E is a component of the core cell cycle machinery, and it drives cell proliferation by regulating entry and progression of cells through the DNA synthesis phase. Cyclin E expression is normally restricted to proliferating cells. However, high levels of cyclin E are expressed in the adult brain. The function of cyclin E in quiescent, postmitotic nervous system remains unknown. Here we use a combination of in vivo quantitative proteomics and analyses of cyclin E knockout mice to demonstrate that in terminally differentiated neurons cyclin E forms complexes with Cdk5 and controls synapse function by restraining Cdk5 activity. Ablation of cyclin E led to a decreased number of synapses, reduced number and volume of dendritic spines, and resulted in impaired synaptic plasticity and memory formation in cyclin E-deficient animals. These results reveal a cell cycle-independent role for a core cell cycle protein, cyclin E, in synapse function and memory."xsd:string |
| http://purl.uniprot.org/citations/21944720 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2011.08.009"xsd:string |
| http://purl.uniprot.org/citations/21944720 | http://purl.uniprot.org/core/author | "Geng Y."xsd:string |
| http://purl.uniprot.org/citations/21944720 | http://purl.uniprot.org/core/author | "Li N."xsd:string |
| http://purl.uniprot.org/citations/21944720 | http://purl.uniprot.org/core/author | "Yu Q."xsd:string |
| http://purl.uniprot.org/citations/21944720 | http://purl.uniprot.org/core/author | "Newman J."xsd:string |
| http://purl.uniprot.org/citations/21944720 | http://purl.uniprot.org/core/author | "Moss S.J."xsd:string |
| http://purl.uniprot.org/citations/21944720 | http://purl.uniprot.org/core/author | "Greenberg M.E."xsd:string |
| http://purl.uniprot.org/citations/21944720 | http://purl.uniprot.org/core/author | "Marto J.A."xsd:string |
| http://purl.uniprot.org/citations/21944720 | http://purl.uniprot.org/core/author | "Das M."xsd:string |
| http://purl.uniprot.org/citations/21944720 | http://purl.uniprot.org/core/author | "Wills Z.P."xsd:string |
| http://purl.uniprot.org/citations/21944720 | http://purl.uniprot.org/core/author | "Sicinski P."xsd:string |
| http://purl.uniprot.org/citations/21944720 | http://purl.uniprot.org/core/author | "Odajima J."xsd:string |
| http://purl.uniprot.org/citations/21944720 | http://purl.uniprot.org/core/author | "Bienvenu F."xsd:string |
| http://purl.uniprot.org/citations/21944720 | http://purl.uniprot.org/core/author | "Kretschmannova K."xsd:string |
| http://purl.uniprot.org/citations/21944720 | http://purl.uniprot.org/core/author | "Terunuma M."xsd:string |
| http://purl.uniprot.org/citations/21944720 | http://purl.uniprot.org/core/author | "Deeb T.Z."xsd:string |
| http://purl.uniprot.org/citations/21944720 | http://purl.uniprot.org/core/author | "Quadros I.M."xsd:string |
| http://purl.uniprot.org/citations/21944720 | http://purl.uniprot.org/core/author | "Gawrzak S."xsd:string |
| http://purl.uniprot.org/citations/21944720 | http://purl.uniprot.org/core/author | "Jecrois M.E."xsd:string |
| http://purl.uniprot.org/citations/21944720 | http://purl.uniprot.org/core/author | "Ndassa Y.M."xsd:string |
| http://purl.uniprot.org/citations/21944720 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21944720 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/21944720 | http://purl.uniprot.org/core/pages | "655-668"xsd:string |