| http://purl.uniprot.org/citations/21946435 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21946435 | http://www.w3.org/2000/01/rdf-schema#comment | "An antiviral innate immune response involves induction of type I interferons (IFNs) and their subsequent autocrine and paracrine actions, but the underlying regulatory mechanisms are incompletely understood. Here we report that CYLD, a deubiquitinase that specifically digests lysine 63-linked ubiquitin chains, is required for antiviral host defense. Loss of CYLD renders mice considerably more susceptible to infection by vesicular stomatitis virus (VSV). Consistently, CYLD-deficient dendritic cells are more sensitive to VSV infection. This functional defect was not due to lack of type I IFN production but rather because of attenuated IFN receptor signaling. In the absence of CYLD, IFN-β is ineffective in the induction of antiviral genes and protection of cells from viral infection. These findings establish CYLD as a novel regulator of antiviral innate immunity and suggest a role for CYLD in regulating IFN receptor signaling."xsd:string |
| http://purl.uniprot.org/citations/21946435 | http://purl.org/dc/terms/identifier | "doi:10.1038/cmi.2011.42"xsd:string |
| http://purl.uniprot.org/citations/21946435 | http://purl.uniprot.org/core/author | "Wu X."xsd:string |
| http://purl.uniprot.org/citations/21946435 | http://purl.uniprot.org/core/author | "Zhang M."xsd:string |
| http://purl.uniprot.org/citations/21946435 | http://purl.uniprot.org/core/author | "Sun S.C."xsd:string |
| http://purl.uniprot.org/citations/21946435 | http://purl.uniprot.org/core/author | "Lee A.J."xsd:string |
| http://purl.uniprot.org/citations/21946435 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21946435 | http://purl.uniprot.org/core/name | "Cell Mol Immunol"xsd:string |
| http://purl.uniprot.org/citations/21946435 | http://purl.uniprot.org/core/pages | "502-504"xsd:string |
| http://purl.uniprot.org/citations/21946435 | http://purl.uniprot.org/core/title | "Regulation of antiviral innate immunity by deubiquitinase CYLD."xsd:string |
| http://purl.uniprot.org/citations/21946435 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/21946435 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21946435 |
| http://purl.uniprot.org/citations/21946435 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21946435 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GSE5-mappedCitation-21946435 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21946435 |
| http://purl.uniprot.org/uniprot/#_Q3UY73-mappedCitation-21946435 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21946435 |
| http://purl.uniprot.org/uniprot/#_Q3V028-mappedCitation-21946435 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21946435 |
| http://purl.uniprot.org/uniprot/#_Q3TJI3-mappedCitation-21946435 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21946435 |
| http://purl.uniprot.org/uniprot/#_Q80TQ2-mappedCitation-21946435 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21946435 |
| http://purl.uniprot.org/uniprot/#_Z4YJJ5-mappedCitation-21946435 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21946435 |
| http://purl.uniprot.org/uniprot/Q80TQ2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21946435 |
| http://purl.uniprot.org/uniprot/Q3TJI3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21946435 |
| http://purl.uniprot.org/uniprot/A0A1B0GSE5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21946435 |
| http://purl.uniprot.org/uniprot/Q3V028 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21946435 |
| http://purl.uniprot.org/uniprot/Q3UY73 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21946435 |