| http://purl.uniprot.org/citations/21947080 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21947080 | http://www.w3.org/2000/01/rdf-schema#comment | "Regulated activation of integrins is critical for cell adhesion, motility and tissue homeostasis. Talin and kindlins activate β1-integrins, but the counteracting inhibiting mechanisms are poorly defined. We identified SHARPIN as an important inactivator of β1-integrins in an RNAi screen. SHARPIN inhibited β1-integrin functions in human cancer cells and primary leukocytes. Fibroblasts, leukocytes and keratinocytes from SHARPIN-deficient mice exhibited increased β1-integrin activity, which was fully rescued by re-expression of SHARPIN. We found that SHARPIN directly binds to a conserved cytoplasmic region of integrin α-subunits and inhibits recruitment of talin and kindlin to the integrin. Therefore, SHARPIN inhibits the critical switching of β1-integrins from inactive to active conformations."xsd:string |
| http://purl.uniprot.org/citations/21947080 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb2340"xsd:string |
| http://purl.uniprot.org/citations/21947080 | http://purl.uniprot.org/core/author | "Potter C.S."xsd:string |
| http://purl.uniprot.org/citations/21947080 | http://purl.uniprot.org/core/author | "Parsons M."xsd:string |
| http://purl.uniprot.org/citations/21947080 | http://purl.uniprot.org/core/author | "Sundberg J.P."xsd:string |
| http://purl.uniprot.org/citations/21947080 | http://purl.uniprot.org/core/author | "Veltel S."xsd:string |
| http://purl.uniprot.org/citations/21947080 | http://purl.uniprot.org/core/author | "Salmi M."xsd:string |
| http://purl.uniprot.org/citations/21947080 | http://purl.uniprot.org/core/author | "Pouwels J."xsd:string |
| http://purl.uniprot.org/citations/21947080 | http://purl.uniprot.org/core/author | "Ivaska J."xsd:string |
| http://purl.uniprot.org/citations/21947080 | http://purl.uniprot.org/core/author | "Duffy T."xsd:string |
| http://purl.uniprot.org/citations/21947080 | http://purl.uniprot.org/core/author | "Rantala J.K."xsd:string |
| http://purl.uniprot.org/citations/21947080 | http://purl.uniprot.org/core/author | "Kallioniemi O."xsd:string |
| http://purl.uniprot.org/citations/21947080 | http://purl.uniprot.org/core/author | "Humphries M.J."xsd:string |
| http://purl.uniprot.org/citations/21947080 | http://purl.uniprot.org/core/author | "Askari J.A."xsd:string |
| http://purl.uniprot.org/citations/21947080 | http://purl.uniprot.org/core/author | "Pellinen T."xsd:string |
| http://purl.uniprot.org/citations/21947080 | http://purl.uniprot.org/core/author | "Mattila E."xsd:string |
| http://purl.uniprot.org/citations/21947080 | http://purl.uniprot.org/core/author | "Laasola P."xsd:string |
| http://purl.uniprot.org/citations/21947080 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21947080 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/21947080 | http://purl.uniprot.org/core/pages | "1315-1324"xsd:string |
| http://purl.uniprot.org/citations/21947080 | http://purl.uniprot.org/core/title | "SHARPIN is an endogenous inhibitor of beta1-integrin activation."xsd:string |
| http://purl.uniprot.org/citations/21947080 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/21947080 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21947080 |
| http://purl.uniprot.org/citations/21947080 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21947080 |