| http://purl.uniprot.org/citations/21948273 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21948273 | http://www.w3.org/2000/01/rdf-schema#comment | "Airway remodelling in asthma involves various mediators modulating the production/breakdown of collagen by lung fibroblasts. Matrix metalloproteinase-1 (MMP-1) plays an important role in collagen breakdown. We recently showed that epithelial cell-derived extracellular form of 14-3-3σ is an important inducer of MMP-1 expression in skin fibroblasts. Thus, we hypothesized that 14-3-3 proteins are important regulators of MMP-1 expression in the respiratory airway. We examined the presence of extracellular 14-3-3 proteins in conditioned media obtained from primary lung epithelial cells, A549 and HS24 cells, and their effect on MMP-1 expression by lung fibroblasts (IMR-90). In addition, we evaluated IMR-90 response to 14-3-3 proteins in the presence of transforming growth factor-β(1) (TGF-β(1)), a cytokine known to decrease MMP-1 expression by fibroblasts. Extracellular 14-3-3α/β, but not -σ, is released by the human-derived lung epithelial cell lines, A549 and HS24. Unlike dermal fibroblasts, IMR-90 cells do not produce MMP-1 in response to 14-3-3σ. Conversely, MMP-1 production was induced following treatment of IMR-90 with recombinant or lung epithelial cell-derived 14-3-3α/β. These findings were also confirmed using primary human bronchial epithelial cells and lung fibroblasts obtained from non-asthmatic patients. The MMP-1-inducing effect of 14-3-3α/β on IMR-90 was not inhibited by TGF-β(1). Lung epithelial cell-derived 14-3-3α/β has a potent MMP-1-inducing effect on airway fibroblasts. Modulation of MMP-1 by 14-3-3α/β, may be important in the alteration of collagenase production associated with airway remodelling in obstructive lung diseases. Our data indicate that 14-3-3 proteins may be potential targets for future therapeutic strategies aimed at modulating tissue remodelling in asthma."xsd:string |
| http://purl.uniprot.org/citations/21948273 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11010-011-1065-1"xsd:string |
| http://purl.uniprot.org/citations/21948273 | http://purl.uniprot.org/core/author | "Kilani R.T."xsd:string |
| http://purl.uniprot.org/citations/21948273 | http://purl.uniprot.org/core/author | "Moqbel R."xsd:string |
| http://purl.uniprot.org/citations/21948273 | http://purl.uniprot.org/core/author | "Odemuyiwa S.O."xsd:string |
| http://purl.uniprot.org/citations/21948273 | http://purl.uniprot.org/core/author | "Knight D.A."xsd:string |
| http://purl.uniprot.org/citations/21948273 | http://purl.uniprot.org/core/author | "Ghahary A."xsd:string |
| http://purl.uniprot.org/citations/21948273 | http://purl.uniprot.org/core/author | "Hackett T.L."xsd:string |
| http://purl.uniprot.org/citations/21948273 | http://purl.uniprot.org/core/author | "Asdaghi N."xsd:string |
| http://purl.uniprot.org/citations/21948273 | http://purl.uniprot.org/core/author | "Hosseini-Tabatabaei A."xsd:string |
| http://purl.uniprot.org/citations/21948273 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/21948273 | http://purl.uniprot.org/core/name | "Mol Cell Biochem"xsd:string |
| http://purl.uniprot.org/citations/21948273 | http://purl.uniprot.org/core/pages | "261-270"xsd:string |
| http://purl.uniprot.org/citations/21948273 | http://purl.uniprot.org/core/title | "Extracellular 14-3-3 from human lung epithelial cells enhances MMP-1 expression."xsd:string |
| http://purl.uniprot.org/citations/21948273 | http://purl.uniprot.org/core/volume | "360"xsd:string |
| http://purl.uniprot.org/citations/21948273 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21948273 |
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