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http://purl.uniprot.org/citations/21948329http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21948329http://www.w3.org/2000/01/rdf-schema#comment"

Objectives

To determine the characteristics of dopamine D2 receptor gene (DRD2) polymorphisms in drug-exposed and unexposed neonates and the relationship to neonatal abstinence syndrome (NAS).

Design

Retrospective case-control analysis between drug-exposed and unexposed infants between DRD2 polymorphisms, drug exposure and NAS treatment.

Patients

Drug-exposed (n=48) and drug-free (n=49) infants born between March 1999 and December 2006.

Methods

Analysis of DNA for the Taq1A, -141Ins/Del and Ser311Cys DRD2 polymorphisms. Drug exposure was determined by antenatal maternal drug and alcohol history. Frequency measures of DRD2 polymorphisms were compared between drug-exposed infants, treatment NAS medication and with control infants.

Setting

Tertiary maternity hospital, Sydney, Australia.

Main outcome measures

All infants were born in a good condition (25.7% <37 weeks gestation). Opiates (methadone and heroin) were used by 45 (93.8%) of drug-exposed mothers. The A2A2 allele was more common in drug-exposed infants (37 (77.0%) versus 23 (46.9%), p=0.003) but the A1A2 allele was more common in control infants (23 (46.9%) versus 4 (8.3%), p=0.00002). The-ins allele was more common in control (39 (79.6%) versus 20 (41.7%), p=<0.01) and unmedicated drug-exposed (14/25 (56%) versus 5/23 (21.7%), p=0.02) infants. The majority of infants (41 (83.7%) controls versus 41 (85.4%), p=1.000) expressed the least common, Ser polymorphism.

Conclusions

DRD2 polymorphisms are detectable from DNA obtained from stored blood spots. The -ins allele is more common in control and unmedicated drug-exposed infants. Further study is recommended to explore postneonatal outcomes especially in relation to neuropsychiatric behaviours."xsd:string
http://purl.uniprot.org/citations/21948329http://purl.org/dc/terms/identifier"doi:10.1136/archdischild-2011-300235"xsd:string
http://purl.uniprot.org/citations/21948329http://purl.uniprot.org/core/author"Lui K."xsd:string
http://purl.uniprot.org/citations/21948329http://purl.uniprot.org/core/author"Xu H.X."xsd:string
http://purl.uniprot.org/citations/21948329http://purl.uniprot.org/core/author"Falconer J."xsd:string
http://purl.uniprot.org/citations/21948329http://purl.uniprot.org/core/author"Feller J.M."xsd:string
http://purl.uniprot.org/citations/21948329http://purl.uniprot.org/core/author"Abdel-Latif M.E."xsd:string
http://purl.uniprot.org/citations/21948329http://purl.uniprot.org/core/author"Al-Amry A."xsd:string
http://purl.uniprot.org/citations/21948329http://purl.uniprot.org/core/author"Clews S."xsd:string
http://purl.uniprot.org/citations/21948329http://purl.uniprot.org/core/author"Oei J.L."xsd:string
http://purl.uniprot.org/citations/21948329http://purl.uniprot.org/core/author"Vunnam K."xsd:string
http://purl.uniprot.org/citations/21948329http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/21948329http://purl.uniprot.org/core/name"Arch Dis Child Fetal Neonatal Ed"xsd:string
http://purl.uniprot.org/citations/21948329http://purl.uniprot.org/core/pages"F193-8"xsd:string
http://purl.uniprot.org/citations/21948329http://purl.uniprot.org/core/title"Dopamine D2 receptor gene polymorphisms in newborn infants of drug-using women."xsd:string
http://purl.uniprot.org/citations/21948329http://purl.uniprot.org/core/volume"97"xsd:string
http://purl.uniprot.org/citations/21948329http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/21948329
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http://purl.uniprot.org/uniprot/#_B5BUP4-mappedCitation-21948329http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21948329
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http://purl.uniprot.org/uniprot/A2N8F4http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/21948329
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