| http://purl.uniprot.org/citations/21949020 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21949020 | http://www.w3.org/2000/01/rdf-schema#comment | "The adapter protein Src homology 2 (SH2) domain-containing leukocyte protein of 76 kDa (SLP-76) is critical for multiple aspects of T cell development and function. Through its protein-binding domains, SLP-76 serves as a platform for the assembly of multiple enzymes and adapter proteins that function together to activate second messengers required for TCR signal propagation. The N terminus of SLP-76, which contains three tyrosines that serve as docking sites for SH2 domain-containing proteins, and the central proline-rich region of SLP-76 have been well studied and are known to be important for both thymocyte selection and activation of peripheral T cells. Less is known about the function of the C-terminal SH2 domain of SLP-76. This region inducibly associates with ADAP and HPK1. Combining regulated deletion of endogenous SLP-76 with transgenic expression of a SLP-76 SH2 domain mutant, we demonstrate that the SLP-76 SH2 domain is required for peripheral T cell activation and positive selection of thymocytes, a function not previously attributed to this region. This domain is also important for T cell proliferation, IL-2 production, and phosphorylation of protein kinase D and IκB. ADAP-deficient T cells display similar, but in some cases less severe, defects despite phosphorylation of a negative regulatory site on SLP-76 by HPK1, a function that is lost in SLP-76 SH2 domain mutant T cells."xsd:string |
| http://purl.uniprot.org/citations/21949020 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0903379"xsd:string |
| http://purl.uniprot.org/citations/21949020 | http://purl.uniprot.org/core/author | "Kliche S."xsd:string |
| http://purl.uniprot.org/citations/21949020 | http://purl.uniprot.org/core/author | "Schraven B."xsd:string |
| http://purl.uniprot.org/citations/21949020 | http://purl.uniprot.org/core/author | "Degen J."xsd:string |
| http://purl.uniprot.org/citations/21949020 | http://purl.uniprot.org/core/author | "Burns J.C."xsd:string |
| http://purl.uniprot.org/citations/21949020 | http://purl.uniprot.org/core/author | "Jordan M.S."xsd:string |
| http://purl.uniprot.org/citations/21949020 | http://purl.uniprot.org/core/author | "Koretzky G.A."xsd:string |
| http://purl.uniprot.org/citations/21949020 | http://purl.uniprot.org/core/author | "Gohil M."xsd:string |
| http://purl.uniprot.org/citations/21949020 | http://purl.uniprot.org/core/author | "Corbo E."xsd:string |
| http://purl.uniprot.org/citations/21949020 | http://purl.uniprot.org/core/author | "Anterasian C."xsd:string |
| http://purl.uniprot.org/citations/21949020 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21949020 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/21949020 | http://purl.uniprot.org/core/pages | "4459-4466"xsd:string |
| http://purl.uniprot.org/citations/21949020 | http://purl.uniprot.org/core/title | "The SLP-76 Src homology 2 domain is required for T cell development and activation."xsd:string |
| http://purl.uniprot.org/citations/21949020 | http://purl.uniprot.org/core/volume | "187"xsd:string |
| http://purl.uniprot.org/citations/21949020 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21949020 |
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