| http://purl.uniprot.org/citations/21949401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21949401 | http://www.w3.org/2000/01/rdf-schema#comment | "Although brain-derived neurotrophic factor (BDNF) is known to regulate circuit development and synaptic plasticity, its exact role in neuronal network activity remains elusive. Using mutant mice (TrkB-PV(-/-)) in which the gene for the BDNF receptor, tyrosine kinase B receptor (trkB), has been specifically deleted in parvalbumin-expressing, fast-spiking GABAergic (PV+) interneurons, we show that TrkB is structurally and functionally important for the integrity of the hippocampal network. The amplitude of glutamatergic inputs to PV+ interneurons and the frequency of GABAergic inputs to excitatory pyramidal cells were reduced in the TrkB-PV(-/-) mice. Functionally, rhythmic network activity in the gamma-frequency band (30-80 Hz) was significantly decreased in hippocampal area CA1. This decrease was caused by a desynchronization and overall reduction in frequency of action potentials generated in PV+ interneurons of TrkB-PV(-/-) mice. Our results show that the integration of PV+ interneurons into the hippocampal microcircuit is impaired in TrkB-PV(-/-) mice, resulting in decreased rhythmic network activity in the gamma-frequency band."xsd:string |
| http://purl.uniprot.org/citations/21949401 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1114241108"xsd:string |
| http://purl.uniprot.org/citations/21949401 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/21949401 | http://purl.uniprot.org/core/author | "Xu W."xsd:string |
| http://purl.uniprot.org/citations/21949401 | http://purl.uniprot.org/core/author | "Xu B."xsd:string |
| http://purl.uniprot.org/citations/21949401 | http://purl.uniprot.org/core/author | "Yang F."xsd:string |
| http://purl.uniprot.org/citations/21949401 | http://purl.uniprot.org/core/author | "Lu B."xsd:string |
| http://purl.uniprot.org/citations/21949401 | http://purl.uniprot.org/core/author | "Zheng K."xsd:string |
| http://purl.uniprot.org/citations/21949401 | http://purl.uniprot.org/core/author | "An J.J."xsd:string |
| http://purl.uniprot.org/citations/21949401 | http://purl.uniprot.org/core/author | "Xu Z.Q."xsd:string |
| http://purl.uniprot.org/citations/21949401 | http://purl.uniprot.org/core/author | "Fisahn A."xsd:string |
| http://purl.uniprot.org/citations/21949401 | http://purl.uniprot.org/core/author | "Hokfelt T.G."xsd:string |
| http://purl.uniprot.org/citations/21949401 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21949401 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/21949401 | http://purl.uniprot.org/core/pages | "17201-17206"xsd:string |
| http://purl.uniprot.org/citations/21949401 | http://purl.uniprot.org/core/title | "TrkB signaling in parvalbumin-positive interneurons is critical for gamma-band network synchronization in hippocampus."xsd:string |
| http://purl.uniprot.org/citations/21949401 | http://purl.uniprot.org/core/volume | "108"xsd:string |
| http://purl.uniprot.org/citations/21949401 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21949401 |
| http://purl.uniprot.org/citations/21949401 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21949401 |
| http://purl.uniprot.org/uniprot/#_A0A286YCV8-mappedCitation-21949401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21949401 |
| http://purl.uniprot.org/uniprot/#_A0A286YDA0-mappedCitation-21949401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21949401 |
| http://purl.uniprot.org/uniprot/#_A0A286YDA3-mappedCitation-21949401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21949401 |
| http://purl.uniprot.org/uniprot/#_A0A286YCB7-mappedCitation-21949401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21949401 |
| http://purl.uniprot.org/uniprot/#_B5BQV3-mappedCitation-21949401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21949401 |