| http://purl.uniprot.org/citations/21953450 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21953450 | http://www.w3.org/2000/01/rdf-schema#comment | "Nuclear factor I-X3 (NFI-X3) is a newly identified splice variant of NFI-X that regulates expression of several astrocyte-specific markers, such as glial fibrillary acidic protein. Here, we identified a set of genes regulated by NFI-X3 that includes a gene encoding a secreted glycoprotein YKL-40. Although YKL-40 expression is up-regulated in glioblastoma multiforme, its regulation and functions in nontransformed cells of the central nervous system are widely unexplored. We find that expression of YKL-40 is activated during brain development and also differentiation of neural progenitors into astrocytes in vitro. Furthermore, YKL-40 is a migration factor for primary astrocytes, and its expression is controlled by both NFI-X3 and STAT3, which are known regulators of gliogenesis. Knockdown of NFI-X3 and STAT3 significantly reduced YKL-40 expression in astrocytes, whereas overexpression of NFI-X3 dramatically enhanced YKL-40 expression in glioma cells. Activation of STAT3 by oncostatin M induced YKL-40 expression in astrocytes, whereas expression of a dominant-negative STAT3 had a suppressive effect. Mechanistically, NFI-X3 and STAT3 form a complex that binds to weak regulatory elements in the YKL-40 promoter and activates transcription. We propose that NFI-X3 and STAT3 control the migration of differentiating astrocytes as well as migration and invasion of glioma cells via regulating YKL-40 expression."xsd:string |
| http://purl.uniprot.org/citations/21953450 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m111.257451"xsd:string |
| http://purl.uniprot.org/citations/21953450 | http://purl.uniprot.org/core/author | "Singh S.K."xsd:string |
| http://purl.uniprot.org/citations/21953450 | http://purl.uniprot.org/core/author | "Kordula T."xsd:string |
| http://purl.uniprot.org/citations/21953450 | http://purl.uniprot.org/core/author | "Bhardwaj R."xsd:string |
| http://purl.uniprot.org/citations/21953450 | http://purl.uniprot.org/core/author | "Dumur C.I."xsd:string |
| http://purl.uniprot.org/citations/21953450 | http://purl.uniprot.org/core/author | "Wilczynska K.M."xsd:string |
| http://purl.uniprot.org/citations/21953450 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21953450 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/21953450 | http://purl.uniprot.org/core/pages | "39893-39903"xsd:string |
| http://purl.uniprot.org/citations/21953450 | http://purl.uniprot.org/core/title | "A complex of nuclear factor I-X3 and STAT3 regulates astrocyte and glioma migration through the secreted glycoprotein YKL-40."xsd:string |
| http://purl.uniprot.org/citations/21953450 | http://purl.uniprot.org/core/volume | "286"xsd:string |
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