| http://purl.uniprot.org/citations/21953641 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21953641 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-23 plays a critical role in the expansion of highly proinflammatory Th17 cells secreting IL-17 and IL-22. Recently, we demonstrated that Notch signaling drives IL-22 secretion through the aryl hydrocarbon receptor (AHR) and plays a protective role in Con A-induced hepatitis. In this study, we investigated the role of IL-23 in hepatitis using IL-23p19- and IL-17-deficient mice. In WT mice, the injection of Con A induced the upregulation of various cytokines, which included IL-23, IL-22, IL-17, IFN-γ and TNF-α. In IL-23p19-deficient mice, exacerbated hepatitis was observed and serum IL-22 and IL-17 levels were greatly reduced, whereas in IL-17-deficient mice, ameliorated hepatitis was observed. The injection of exogenous IL-22 protected p19-deficient mice from hepatitis, whereas the injection of exogenous IL-23 significantly increased the serum levels of not only IL-22 but also IL-17, and less effectively protected against hepatitis in IL-17-dependent and -independent manners. Finally, it was revealed that STAT3, STAT4 and Notch contributed to the production of both the cytokines, and that the AHR was important only for IL-22 production in response to Con A and IL-23 in liver mononuclear cells. These results suggest that IL-23 plays a protective role in hepatitis through IL-22 production and also a pathological role via IL-17-dependent and -independent mechanisms."xsd:string |
| http://purl.uniprot.org/citations/21953641 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201141291"xsd:string |
| http://purl.uniprot.org/citations/21953641 | http://purl.uniprot.org/core/author | "Chiba Y."xsd:string |
| http://purl.uniprot.org/citations/21953641 | http://purl.uniprot.org/core/author | "Fujita K."xsd:string |
| http://purl.uniprot.org/citations/21953641 | http://purl.uniprot.org/core/author | "Kuroda M."xsd:string |
| http://purl.uniprot.org/citations/21953641 | http://purl.uniprot.org/core/author | "Mizuguchi J."xsd:string |
| http://purl.uniprot.org/citations/21953641 | http://purl.uniprot.org/core/author | "Xu M."xsd:string |
| http://purl.uniprot.org/citations/21953641 | http://purl.uniprot.org/core/author | "Yoshimoto T."xsd:string |
| http://purl.uniprot.org/citations/21953641 | http://purl.uniprot.org/core/author | "Iwakura Y."xsd:string |
| http://purl.uniprot.org/citations/21953641 | http://purl.uniprot.org/core/author | "Morishima N."xsd:string |
| http://purl.uniprot.org/citations/21953641 | http://purl.uniprot.org/core/author | "Cua D.J."xsd:string |
| http://purl.uniprot.org/citations/21953641 | http://purl.uniprot.org/core/author | "Yasutomo K."xsd:string |
| http://purl.uniprot.org/citations/21953641 | http://purl.uniprot.org/core/author | "Mizoguchi I."xsd:string |
| http://purl.uniprot.org/citations/21953641 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21953641 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/21953641 | http://purl.uniprot.org/core/pages | "2828-2839"xsd:string |
| http://purl.uniprot.org/citations/21953641 | http://purl.uniprot.org/core/title | "Regulation of the development of acute hepatitis by IL-23 through IL-22 and IL-17 production."xsd:string |
| http://purl.uniprot.org/citations/21953641 | http://purl.uniprot.org/core/volume | "41"xsd:string |
| http://purl.uniprot.org/citations/21953641 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21953641 |
| http://purl.uniprot.org/citations/21953641 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21953641 |
| http://purl.uniprot.org/uniprot/#_A0A7R8GV04-mappedCitation-21953641 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21953641 |
| http://purl.uniprot.org/uniprot/#_B7ZC18-mappedCitation-21953641 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21953641 |
| http://purl.uniprot.org/uniprot/#_Q62386-mappedCitation-21953641 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21953641 |
| http://purl.uniprot.org/uniprot/#_Q3ULI4-mappedCitation-21953641 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21953641 |