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http://purl.uniprot.org/citations/21953935 | http://www.w3.org/2000/01/rdf-schema#comment | "Uch37 is a de-ubiquitylating enzyme that is functionally linked with the 26S proteasome via Rpn13, and is essential for metazoan development. Here, we report the X-ray crystal structure of full-length human Uch37 at 2.95 Å resolution. Uch37's catalytic domain is similar to those of all UCH enzymes characterized to date. The C-terminal extension is elongated, predominantly helical and contains coiled coil interactions. Additionally, we provide an initial characterization of Uch37's oligomeric state and identify a systematic error in previous analyses of Uch37 activity. Taken together, these data provide a strong foundation for further analysis of Uch37's several functions."xsd:string |
http://purl.uniprot.org/citations/21953935 | http://purl.org/dc/terms/identifier | "doi:10.1002/prot.23147"xsd:string |
http://purl.uniprot.org/citations/21953935 | http://purl.uniprot.org/core/author | "Bingman C.A."xsd:string |
http://purl.uniprot.org/citations/21953935 | http://purl.uniprot.org/core/author | "Phillips G.N. Jr."xsd:string |
http://purl.uniprot.org/citations/21953935 | http://purl.uniprot.org/core/author | "Burgie S.E."xsd:string |
http://purl.uniprot.org/citations/21953935 | http://purl.uniprot.org/core/author | "Soni A.B."xsd:string |
http://purl.uniprot.org/citations/21953935 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
http://purl.uniprot.org/citations/21953935 | http://purl.uniprot.org/core/name | "Proteins"xsd:string |
http://purl.uniprot.org/citations/21953935 | http://purl.uniprot.org/core/pages | "649-654"xsd:string |
http://purl.uniprot.org/citations/21953935 | http://purl.uniprot.org/core/title | "Structural characterization of human Uch37."xsd:string |
http://purl.uniprot.org/citations/21953935 | http://purl.uniprot.org/core/volume | "80"xsd:string |
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