| http://purl.uniprot.org/citations/21954290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21954290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21954290 | http://www.w3.org/2000/01/rdf-schema#comment | "GIV (Gα-interacting vesicle-associated protein; also known as Girdin) enhances Akt activation downstream of multiple growth factor- and G protein (heterotrimeric guanosine 5'-triphosphate-binding protein)-coupled receptors to trigger cell migration and cancer invasion. We demonstrate that GIV is a tyrosine phosphoprotein that directly binds to and activates phosphoinositide 3-kinase (PI3K). Upon ligand stimulation of various receptors, GIV was phosphorylated at tyrosine-1764 and tyrosine-1798 by both receptor and non-receptor tyrosine kinases. These phosphorylation events enabled direct binding of GIV to the amino- and carboxyl-terminal Src homology 2 domains of p85α, a regulatory subunit of PI3K; stabilized receptor association with PI3K; and enhanced PI3K activity at the plasma membrane to trigger cell migration. Tyrosine phosphorylation of GIV and its association with p85α increased during metastatic progression of a breast carcinoma. These results suggest a mechanism by which multiple receptors activate PI3K through tyrosine phosphorylation of GIV, thereby making the GIV-PI3K interaction a potential therapeutic target within the PI3K-Akt pathway."xsd:string |
| http://purl.uniprot.org/citations/21954290 | http://purl.org/dc/terms/identifier | "doi:10.1126/scisignal.2002049"xsd:string |
| http://purl.uniprot.org/citations/21954290 | http://purl.org/dc/terms/identifier | "doi:10.1126/scisignal.2002049"xsd:string |
| http://purl.uniprot.org/citations/21954290 | http://purl.uniprot.org/core/author | "Ghosh P."xsd:string |
| http://purl.uniprot.org/citations/21954290 | http://purl.uniprot.org/core/author | "Ghosh P."xsd:string |
| http://purl.uniprot.org/citations/21954290 | http://purl.uniprot.org/core/author | "Lin C."xsd:string |
| http://purl.uniprot.org/citations/21954290 | http://purl.uniprot.org/core/author | "Lin C."xsd:string |
| http://purl.uniprot.org/citations/21954290 | http://purl.uniprot.org/core/author | "Abagyan R."xsd:string |
| http://purl.uniprot.org/citations/21954290 | http://purl.uniprot.org/core/author | "Abagyan R."xsd:string |
| http://purl.uniprot.org/citations/21954290 | http://purl.uniprot.org/core/author | "Ghassemian M."xsd:string |
| http://purl.uniprot.org/citations/21954290 | http://purl.uniprot.org/core/author | "Ghassemian M."xsd:string |
| http://purl.uniprot.org/citations/21954290 | http://purl.uniprot.org/core/author | "Kufareva I."xsd:string |
| http://purl.uniprot.org/citations/21954290 | http://purl.uniprot.org/core/author | "Kufareva I."xsd:string |
| http://purl.uniprot.org/citations/21954290 | http://purl.uniprot.org/core/author | "Pavlova Y."xsd:string |
| http://purl.uniprot.org/citations/21954290 | http://purl.uniprot.org/core/author | "Pavlova Y."xsd:string |
| http://purl.uniprot.org/citations/21954290 | http://purl.uniprot.org/core/author | "Ear J."xsd:string |
| http://purl.uniprot.org/citations/21954290 | http://purl.uniprot.org/core/author | "Ear J."xsd:string |
| http://purl.uniprot.org/citations/21954290 | http://purl.uniprot.org/core/author | "Garcia-Marcos M."xsd:string |
| http://purl.uniprot.org/citations/21954290 | http://purl.uniprot.org/core/author | "Garcia-Marcos M."xsd:string |
| http://purl.uniprot.org/citations/21954290 | http://purl.uniprot.org/core/author | "Mittal Y."xsd:string |
| http://purl.uniprot.org/citations/21954290 | http://purl.uniprot.org/core/author | "Mittal Y."xsd:string |
| http://purl.uniprot.org/citations/21954290 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21954290 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |