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http://purl.uniprot.org/citations/21955323http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21955323http://www.w3.org/2000/01/rdf-schema#comment"

Background

Metastasis-associated in colon cancer-1 (MACC1) is a newly identified gene that plays a role in colon cancer metastasis through upregulation of c-MET proto-oncogene (c-MET). However, the value of MACC1 as a potential biomarker for hepatocellular carcinoma (HCC) remains unknown.

Methods

MACC1 mRNA expression in 128 HCC tissues was examined by quantitative polymerase chain reaction. To show the potential correlation of MACC1 and c-MET, c-MET was also analysed.

Results

MACC1 was more highly expressed in HCC than in non-HCC tissues (P = 0.009). High MACC1 expression was significantly increased in cases with high alpha fetoprotein (AFP) (P = 0.025). A positive correlation was found between MACC1 and c-MET mRNAs (r = 0.235, P = 0.009). Both univariate and multivariate analyses revealed that MACC1 expression was associated with overall survival (OS) and disease-free survival (DFS). Moreover, stratified analysis showed that tumour-node-metastasis (TNM) stage I patients with high MACC1 levels had shorter OS and DFS than those with low MACC1.

Conclusions

MACC1 may identify low- and high-risk individuals with HCC and be a valuable indicator for stratifying the prognosis of TNM stage I patients. MACC1 may serve as a novel biomarker for HCC."xsd:string
http://purl.uniprot.org/citations/21955323http://purl.org/dc/terms/identifier"doi:10.1186/1479-5876-9-166"xsd:string
http://purl.uniprot.org/citations/21955323http://purl.uniprot.org/core/author"Huang P."xsd:string
http://purl.uniprot.org/citations/21955323http://purl.uniprot.org/core/author"Liu Q."xsd:string
http://purl.uniprot.org/citations/21955323http://purl.uniprot.org/core/author"Li B."xsd:string
http://purl.uniprot.org/citations/21955323http://purl.uniprot.org/core/author"Lu C."xsd:string
http://purl.uniprot.org/citations/21955323http://purl.uniprot.org/core/author"Qiu J."xsd:string
http://purl.uniprot.org/citations/21955323http://purl.uniprot.org/core/author"Hong J."xsd:string
http://purl.uniprot.org/citations/21955323http://purl.uniprot.org/core/author"Wang J."xsd:string
http://purl.uniprot.org/citations/21955323http://purl.uniprot.org/core/author"Wang L."xsd:string
http://purl.uniprot.org/citations/21955323http://purl.uniprot.org/core/author"Yuan Y."xsd:string
http://purl.uniprot.org/citations/21955323http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/21955323http://purl.uniprot.org/core/name"J Transl Med"xsd:string
http://purl.uniprot.org/citations/21955323http://purl.uniprot.org/core/pages"166"xsd:string
http://purl.uniprot.org/citations/21955323http://purl.uniprot.org/core/title"Identification of MACC1 as a novel prognostic marker in hepatocellular carcinoma."xsd:string
http://purl.uniprot.org/citations/21955323http://purl.uniprot.org/core/volume"9"xsd:string
http://purl.uniprot.org/citations/21955323http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/21955323
http://purl.uniprot.org/citations/21955323http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/21955323
http://purl.uniprot.org/uniprot/#_Q6ZN28-mappedCitation-21955323http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21955323
http://purl.uniprot.org/uniprot/Q6ZN28http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/21955323