| http://purl.uniprot.org/citations/2196173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2196173 | http://www.w3.org/2000/01/rdf-schema#comment | "Colony-stimulating factor 1 (CSF-1) is required for the survival, proliferation and differentiation of monocytes. We previously demonstrated that the CSF-1 receptor is linked to a pertussis toxin-sensitive G protein and that the induction of Na+ influx by CSF-1 is a pertussis toxin-sensitive event. The present studies have examined activation of protein kinase C as a potential intracellular signaling event induced by the activated CSF-1 receptor. The results demonstrate that CSF-1 stimulates translocation of protein kinase C activity from the cytosol to membrane fractions. This activation of protein kinase C was sensitive to pretreatment of the monocytes with pertussis toxin. Lipid distribution studies demonstrated that phosphatidylcholine (PC) is the major phospholipid in human monocytes. Moreover, the results indicate that CSF-1 stimulation is associated with decreases in PC, but not in phosphatidylinositol (PI), levels. The absence of an effect of CSF-1 on PI turnover was confirmed by the lack of changes in inositol phosphate production. In contrast, CSF-1 stimulation was associated with increased hydrolysis of PC to phosphorylcholine and diacylglycerol (DAG) in both intact monocytes and cell-free assays. Furthermore, the increase in PC turnover induced by CSF-1 was sensitive to pertussis toxin. The results also demonstrate that the induction of Na+ influx by CSF-1 is inhibited by the protein kinase C inhibitors staurosporine and the isoquinoline derivative H7, but not by HA1004.(ABSTRACT TRUNCATED AT 250 WORDS)"xsd:string |
| http://purl.uniprot.org/citations/2196173 | http://purl.org/dc/terms/identifier | "doi:10.1002/j.1460-2075.1990.tb07418.x"xsd:string |
| http://purl.uniprot.org/citations/2196173 | http://purl.uniprot.org/core/author | "Imamura K."xsd:string |
| http://purl.uniprot.org/citations/2196173 | http://purl.uniprot.org/core/author | "Nakamura T."xsd:string |
| http://purl.uniprot.org/citations/2196173 | http://purl.uniprot.org/core/author | "Kufe D."xsd:string |
| http://purl.uniprot.org/citations/2196173 | http://purl.uniprot.org/core/author | "Dianoux A."xsd:string |
| http://purl.uniprot.org/citations/2196173 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/2196173 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/2196173 | http://purl.uniprot.org/core/pages | "2423-2428"xsd:string |
| http://purl.uniprot.org/citations/2196173 | http://purl.uniprot.org/core/title | "Colony-stimulating factor 1 activates protein kinase C in human monocytes."xsd:string |
| http://purl.uniprot.org/citations/2196173 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/2196173 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2196173 |
| http://purl.uniprot.org/citations/2196173 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/2196173 |
| http://purl.uniprot.org/uniprot/#_P42224-mappedCitation-2196173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2196173 |
| http://purl.uniprot.org/uniprot/#_P06241-mappedCitation-2196173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2196173 |
| http://purl.uniprot.org/uniprot/#_P27986-mappedCitation-2196173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2196173 |
| http://purl.uniprot.org/uniprot/#_O75791-mappedCitation-2196173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2196173 |
| http://purl.uniprot.org/uniprot/#_P42338-mappedCitation-2196173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2196173 |
| http://purl.uniprot.org/uniprot/#_O15357-mappedCitation-2196173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2196173 |
| http://purl.uniprot.org/uniprot/#_P16885-mappedCitation-2196173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2196173 |
| http://purl.uniprot.org/uniprot/#_P07947-mappedCitation-2196173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2196173 |
| http://purl.uniprot.org/uniprot/#_P07948-mappedCitation-2196173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2196173 |
| http://purl.uniprot.org/uniprot/#_P08631-mappedCitation-2196173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2196173 |
| http://purl.uniprot.org/uniprot/#_P09603-mappedCitation-2196173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2196173 |