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| http://purl.uniprot.org/citations/21963652 | http://www.w3.org/2000/01/rdf-schema#comment | "Attention system abnormalities represent a significant barrier to scholastic achievement in children with neurofibromatosis-1 (NF1). Using a novel mouse model of NF1-associated attention deficit (ADD), we demonstrate a presynaptic defect in striatal dopaminergic homeostasis and leverage this finding to apply [(11)C]-raclopride positron-emission tomography (PET) in the intact animal. While methylphenidate and l-Deprenyl correct both striatal dopamine levels on PET imaging and defective attention system function in Nf1 mutant mice, pharmacologic agents that target de-regulated cyclic AMP and RAS signaling in these mice do not. These studies establish a robust preclinical model to evaluate promising agents for NF1-associated ADD."xsd:string |
| http://purl.uniprot.org/citations/21963652 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.expneurol.2011.09.005"xsd:string |
| http://purl.uniprot.org/citations/21963652 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/21963652 | http://purl.uniprot.org/core/author | "Wozniak D.F."xsd:string |
| http://purl.uniprot.org/citations/21963652 | http://purl.uniprot.org/core/author | "Brown J.A."xsd:string |
| http://purl.uniprot.org/citations/21963652 | http://purl.uniprot.org/core/author | "Gutmann D.H."xsd:string |
| http://purl.uniprot.org/citations/21963652 | http://purl.uniprot.org/core/author | "Mach R.H."xsd:string |
| http://purl.uniprot.org/citations/21963652 | http://purl.uniprot.org/core/author | "Diggs-Andrews K.A."xsd:string |
| http://purl.uniprot.org/citations/21963652 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21963652 | http://purl.uniprot.org/core/name | "Exp Neurol"xsd:string |
| http://purl.uniprot.org/citations/21963652 | http://purl.uniprot.org/core/pages | "333-338"xsd:string |
| http://purl.uniprot.org/citations/21963652 | http://purl.uniprot.org/core/title | "PET imaging for attention deficit preclinical drug testing in neurofibromatosis-1 mice."xsd:string |
| http://purl.uniprot.org/citations/21963652 | http://purl.uniprot.org/core/volume | "232"xsd:string |
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