| http://purl.uniprot.org/citations/21964029 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21964029 | http://www.w3.org/2000/01/rdf-schema#comment | "NKT cells respond to a variety of CD1d-restricted glycolipid Ags that are structurally related to the prototypic Ag α-galactosylceramide (α-GalCer). A modified analog of α-GalCer with a carbon-based glycosidic linkage (α-C-GalCer) has generated great interest because of its apparent ability to promote prolonged, Th1-biased immune responses. In this study, we report the activation of spleen NKT cells to α-C-GalCer, and related C-glycoside ligands, is weaker than that of α-GalCer. Furthermore, the Vβ8.2 and Vβ7 NKT TCR affinity for CD1d-α-C-GalCer, and some related analogs, is ∼10-fold lower than that for the NKT TCR-CD1d-α-GalCer interaction. Nevertheless, the crystal structure of the Vβ8.2 NKT TCR-CD1d-α-C-GalCer complex is similar to that of the corresponding NKT TCR-CD1d-α-GalCer complex, although subtle differences at the interface provide a basis for understanding the lower affinity of the NKT TCR-CD1d-α-C-GalCer interaction. Our findings support the concept that for CD1d-restricted NKT cells, altered glycolipid ligands can promote markedly different responses while adopting similar TCR-docking topologies."xsd:string |
| http://purl.uniprot.org/citations/21964029 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1100794"xsd:string |
| http://purl.uniprot.org/citations/21964029 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/21964029 | http://purl.uniprot.org/core/author | "Rossjohn J."xsd:string |
| http://purl.uniprot.org/citations/21964029 | http://purl.uniprot.org/core/author | "Godfrey D.I."xsd:string |
| http://purl.uniprot.org/citations/21964029 | http://purl.uniprot.org/core/author | "Pellicci D.G."xsd:string |
| http://purl.uniprot.org/citations/21964029 | http://purl.uniprot.org/core/author | "Beddoe T."xsd:string |
| http://purl.uniprot.org/citations/21964029 | http://purl.uniprot.org/core/author | "McCluskey J."xsd:string |
| http://purl.uniprot.org/citations/21964029 | http://purl.uniprot.org/core/author | "Patel O."xsd:string |
| http://purl.uniprot.org/citations/21964029 | http://purl.uniprot.org/core/author | "Bittman R."xsd:string |
| http://purl.uniprot.org/citations/21964029 | http://purl.uniprot.org/core/author | "Porcelli S.A."xsd:string |
| http://purl.uniprot.org/citations/21964029 | http://purl.uniprot.org/core/author | "Cameron G."xsd:string |
| http://purl.uniprot.org/citations/21964029 | http://purl.uniprot.org/core/author | "Castano A.R."xsd:string |
| http://purl.uniprot.org/citations/21964029 | http://purl.uniprot.org/core/author | "Byun H.S."xsd:string |
| http://purl.uniprot.org/citations/21964029 | http://purl.uniprot.org/core/author | "Franck R.W."xsd:string |
| http://purl.uniprot.org/citations/21964029 | http://purl.uniprot.org/core/author | "Llebaria A."xsd:string |
| http://purl.uniprot.org/citations/21964029 | http://purl.uniprot.org/core/author | "Harrak Y."xsd:string |
| http://purl.uniprot.org/citations/21964029 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21964029 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/21964029 | http://purl.uniprot.org/core/pages | "4705-4713"xsd:string |
| http://purl.uniprot.org/citations/21964029 | http://purl.uniprot.org/core/title | "NKT TCR recognition of CD1d-alpha-C-galactosylceramide."xsd:string |
| http://purl.uniprot.org/citations/21964029 | http://purl.uniprot.org/core/volume | "187"xsd:string |
| http://purl.uniprot.org/citations/21964029 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21964029 |
| http://purl.uniprot.org/citations/21964029 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21964029 |