| http://purl.uniprot.org/citations/21965616 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21965616 | http://www.w3.org/2000/01/rdf-schema#comment | "Tight regulation of self-renewal and differentiation of adult stem cells ensures that tissues are properly maintained. In the Drosophila intestine, both commitment, i.e. exit from self-renewal, and terminal differentiation are controlled by Notch signaling. Here, we show that distinct requirements for Notch activity exist: commitment requires high Notch activity, whereas terminal differentiation can occur with lower Notch activity. We identified the gene GDP-mannose 4,6-dehydratase (Gmd), a modulator of Notch signaling, as being required for commitment but dispensable for terminal differentiation. Gmd loss resulted in aberrant, self-renewing stem cell divisions that generated extra ISC-like cells defective in Notch reporter activation, as well as wild-type-like cell divisions that produced properly terminally differentiated cells. Lowering Notch signaling using additional genetic means, we provided further evidence that commitment has a higher Notch signaling requirement than terminal differentiation. Our work suggests that a commitment requirement for high-level Notch activity safeguards the stem cells from loss through differentiation, revealing a novel role for the importance of Notch signaling levels in this system."xsd:string |
| http://purl.uniprot.org/citations/21965616 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.065292"xsd:string |
| http://purl.uniprot.org/citations/21965616 | http://purl.uniprot.org/core/author | "Bardin A.J."xsd:string |
| http://purl.uniprot.org/citations/21965616 | http://purl.uniprot.org/core/author | "Schweisguth F."xsd:string |
| http://purl.uniprot.org/citations/21965616 | http://purl.uniprot.org/core/author | "Perdigoto C.N."xsd:string |
| http://purl.uniprot.org/citations/21965616 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21965616 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/21965616 | http://purl.uniprot.org/core/pages | "4585-4595"xsd:string |
| http://purl.uniprot.org/citations/21965616 | http://purl.uniprot.org/core/title | "Distinct levels of Notch activity for commitment and terminal differentiation of stem cells in the adult fly intestine."xsd:string |
| http://purl.uniprot.org/citations/21965616 | http://purl.uniprot.org/core/volume | "138"xsd:string |
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